Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 30598..31241 Replicon plasmid pWYKP586-2
Accession NZ_CP125336
Organism Klebsiella pneumoniae strain WYKP586

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag QJR21_RS28835 Protein ID WP_001044770.1
Coordinates 30598..31014 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag QJR21_RS28840 Protein ID WP_001261282.1
Coordinates 31011..31241 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR21_RS28815 (26701) 26701..26973 - 273 Protein_33 transposase -
QJR21_RS28825 (27955) 27955..28977 - 1023 WP_000361404.1 helicase UvrD -
QJR21_RS28830 (28962) 28962..30524 - 1563 WP_004206609.1 AAA family ATPase -
QJR21_RS28835 (30598) 30598..31014 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
QJR21_RS28840 (31011) 31011..31241 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJR21_RS28845 (31198) 31198..31659 + 462 WP_014343465.1 hypothetical protein -
QJR21_RS28850 (31820) 31820..32764 + 945 WP_011977810.1 hypothetical protein -
QJR21_RS28855 (32801) 32801..33193 + 393 WP_011977811.1 hypothetical protein -
QJR21_RS28860 (33251) 33251..33772 + 522 WP_013214008.1 hypothetical protein -
QJR21_RS28865 (33818) 33818..34021 + 204 WP_011977813.1 hypothetical protein -
QJR21_RS28870 (34051) 34051..35055 + 1005 WP_011977814.1 hypothetical protein -
QJR21_RS28875 (35239) 35239..36018 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / blaKPC-2 - 1..110449 110449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T282022 WP_001044770.1 NZ_CP125336:c31014-30598 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT282022 WP_001261282.1 NZ_CP125336:c31241-31011 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References