Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4900448..4900964 Replicon chromosome
Accession NZ_CP125334
Organism Klebsiella pneumoniae strain WYKP586

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QJR21_RS24325 Protein ID WP_002886902.1
Coordinates 4900448..4900732 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QJR21_RS24330 Protein ID WP_002886901.1
Coordinates 4900722..4900964 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR21_RS24300 (QJR21_24300) 4895932..4896195 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QJR21_RS24305 (QJR21_24305) 4896325..4896498 + 174 WP_002886906.1 hypothetical protein -
QJR21_RS24310 (QJR21_24310) 4896501..4897244 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QJR21_RS24315 (QJR21_24315) 4897601..4899739 + 2139 WP_217289782.1 anaerobic ribonucleoside-triphosphate reductase -
QJR21_RS24320 (QJR21_24320) 4899980..4900444 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJR21_RS24325 (QJR21_24325) 4900448..4900732 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJR21_RS24330 (QJR21_24330) 4900722..4900964 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJR21_RS24335 (QJR21_24335) 4901042..4902952 - 1911 WP_004152270.1 PRD domain-containing protein -
QJR21_RS24340 (QJR21_24340) 4902975..4904129 - 1155 WP_002886900.1 lactonase family protein -
QJR21_RS24345 (QJR21_24345) 4904195..4904935 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T282016 WP_002886902.1 NZ_CP125334:c4900732-4900448 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT282016 WP_002886901.1 NZ_CP125334:c4900964-4900722 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References