Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/ElaA-DUF1778
Location 44860..45657 Replicon plasmid pCF5125-1
Accession NZ_CP125311
Organism Citrobacter freundii strain CF5125

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag QKW62_RS26330 Protein ID WP_172754447.1
Coordinates 45154..45657 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A5D4NAG3
Locus tag QKW62_RS26325 Protein ID WP_016582626.1
Coordinates 44860..45129 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW62_RS26300 (QKW62_26295) 40483..41208 - 726 WP_071684184.1 hypothetical protein -
QKW62_RS26305 (QKW62_26300) 41490..42545 + 1056 WP_001238819.1 hypothetical protein -
QKW62_RS26310 (QKW62_26305) 42615..43370 - 756 WP_071684185.1 DUF2971 domain-containing protein -
QKW62_RS26315 (QKW62_26310) 43419..43772 - 354 WP_162199642.1 hypothetical protein -
QKW62_RS26320 (QKW62_26315) 43778..44443 - 666 WP_023315962.1 AAA family ATPase -
QKW62_RS26325 (QKW62_26320) 44860..45129 + 270 WP_016582626.1 DUF1778 domain-containing protein Antitoxin
QKW62_RS26330 (QKW62_26325) 45154..45657 + 504 WP_172754447.1 GNAT family N-acetyltransferase Toxin
QKW62_RS26335 (QKW62_26330) 45685..45849 - 165 WP_230131714.1 hypothetical protein -
QKW62_RS26340 (QKW62_26335) 45842..46093 - 252 WP_004109798.1 hypothetical protein -
QKW62_RS26345 (QKW62_26340) 46095..46787 - 693 WP_071684138.1 hypothetical protein -
QKW62_RS26350 (QKW62_26345) 46801..47124 - 324 WP_000064173.1 hypothetical protein -
QKW62_RS26355 (QKW62_26350) 47199..47987 - 789 WP_071684139.1 receptor-recognizing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111042 111042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-142)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18603.30 Da        Isoelectric Point: 8.8869

>T281992 WP_172754447.1 NZ_CP125311:45154-45657 [Citrobacter freundii]
MFSAQAVYDFSGFDCGEPSLNDFLQNRLVQQHNGRILRGYLLLTKDPVPKVKGFYTLSGSCFARQTLPSNTQKRKIPYAD
APSVTLGRLAIDISLQKQGYGEVLVTHALKVVYQASRAVGIYALFVDALNQSAMQFYQKFGFIPLTGANANSLFYPTKSI
EELFETE

Download         Length: 504 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10113.57 Da        Isoelectric Point: 5.8580

>AT281992 WP_016582626.1 NZ_CP125311:44860-45129 [Citrobacter freundii]
MSALKKQRIDLRLTDDDKSMIEEAAAMTNQTITQFMVASASERAAEVIEQHRRLILSEESWNLVMDAISNPPAPNDRLKR
AAKRLQSME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5D4NAG3

References