Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4387919..4388573 Replicon chromosome
Accession NZ_CP125310
Organism Citrobacter freundii strain CF5125

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag QKW62_RS21810 Protein ID WP_003026936.1
Coordinates 4387919..4388326 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag QKW62_RS21815 Protein ID WP_003026938.1
Coordinates 4388307..4388573 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW62_RS21790 (4383867) 4383867..4385600 - 1734 WP_054528765.1 single-stranded-DNA-specific exonuclease RecJ -
QKW62_RS21795 (4385606) 4385606..4386319 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QKW62_RS21800 (4386343) 4386343..4387239 - 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
QKW62_RS21805 (4387353) 4387353..4387874 + 522 WP_003026933.1 flavodoxin FldB -
QKW62_RS21810 (4387919) 4387919..4388326 - 408 WP_003026936.1 protein YgfX Toxin
QKW62_RS21815 (4388307) 4388307..4388573 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
QKW62_RS21820 (4388563) 4388563..4388790 - 228 WP_003026941.1 hypothetical protein -
QKW62_RS21825 (4388830) 4388830..4389810 + 981 WP_003026944.1 tRNA-modifying protein YgfZ -
QKW62_RS21830 (4389904) 4389904..4390563 - 660 WP_003838267.1 hemolysin III family protein -
QKW62_RS21835 (4390726) 4390726..4391037 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
QKW62_RS21840 (4391090) 4391090..4391818 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
QKW62_RS21845 (4391939) 4391939..4393372 + 1434 WP_054528766.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T281987 WP_003026936.1 NZ_CP125310:c4388326-4387919 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT281987 WP_003026938.1 NZ_CP125310:c4388573-4388307 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References