281978

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1532482..1533102 Replicon chromosome
Accession NZ_CP125310
Organism Citrobacter freundii strain CF5125

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag QKW62_RS07435 Protein ID WP_002892050.1
Coordinates 1532482..1532700 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag QKW62_RS07440 Protein ID WP_003021733.1
Coordinates 1532728..1533102 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW62_RS07400 (1527833) 1527833..1528462 + 630 WP_054528154.1 membrane protein -
QKW62_RS07405 (1528527) 1528527..1528880 + 354 WP_003831033.1 DUF1428 family protein -
QKW62_RS07410 (1528932) 1528932..1530492 - 1561 Protein_1437 EAL domain-containing protein -
QKW62_RS07415 (1530681) 1530681..1530941 + 261 WP_003021719.1 type B 50S ribosomal protein L31 -
QKW62_RS07420 (1530943) 1530943..1531083 + 141 WP_005125190.1 type B 50S ribosomal protein L36 -
QKW62_RS07425 (1531162) 1531162..1531632 - 471 WP_003021724.1 YlaC family protein -
QKW62_RS07430 (1531749) 1531749..1532300 - 552 WP_003021728.1 maltose O-acetyltransferase -
QKW62_RS07435 (1532482) 1532482..1532700 - 219 WP_002892050.1 HHA domain-containing protein Toxin
QKW62_RS07440 (1532728) 1532728..1533102 - 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
QKW62_RS07445 (1533591) 1533591..1536740 - 3150 WP_003021736.1 efflux RND transporter permease AcrB -
QKW62_RS07450 (1536763) 1536763..1537956 - 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T281978 WP_002892050.1 NZ_CP125310:c1532700-1532482 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT281978 WP_003021733.1 NZ_CP125310:c1533102-1532728 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References