281975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 304206..304872 Replicon chromosome
Accession NZ_CP125310
Organism Citrobacter freundii strain CF5125

Toxin (Protein)


Gene name tad Uniprot ID A0A0J1MRN0
Locus tag QKW62_RS01450 Protein ID WP_032938228.1
Coordinates 304206..304565 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A0J1QJH0
Locus tag QKW62_RS01455 Protein ID WP_032938223.1
Coordinates 304555..304872 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW62_RS01440 (301606) 301606..303237 + 1632 WP_003031618.1 Na/Pi cotransporter family protein -
QKW62_RS01445 (303303) 303303..303992 - 690 WP_003841421.1 dipeptidase PepE -
QKW62_RS01450 (304206) 304206..304565 + 360 WP_032938228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QKW62_RS01455 (304555) 304555..304872 + 318 WP_032938223.1 helix-turn-helix transcriptional regulator Antitoxin
QKW62_RS01460 (305012) 305012..305173 - 162 WP_003841416.1 phage protein -
QKW62_RS01465 (305244) 305244..305417 - 174 WP_032938222.1 hypothetical protein -
QKW62_RS01470 (305549) 305549..305914 + 366 WP_054527949.1 hypothetical protein -
QKW62_RS01475 (306011) 306011..306304 + 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
QKW62_RS01480 (306304) 306304..306621 + 318 WP_054527950.1 CcdB family protein -
QKW62_RS01485 (306655) 306655..307467 - 813 WP_048234164.1 shikimate 5-dehydrogenase -
QKW62_RS01490 (307469) 307469..308692 - 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
QKW62_RS01495 (308761) 308761..309585 - 825 WP_003031641.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13411.37 Da        Isoelectric Point: 10.3350

>T281975 WP_032938228.1 NZ_CP125310:304206-304565 [Citrobacter freundii]
MTKPLYWVGHARKDLQGMPEHVRDTFGFALWLAQQGKQHSQTKSLKGFGGAGVLEVVEDHHGNAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVT

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11451.29 Da        Isoelectric Point: 6.9796

>AT281975 WP_032938223.1 NZ_CP125310:304555-304872 [Citrobacter freundii]
MSHEVEASSGNVYADLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGEEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MRN0

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1QJH0

References