Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4140417..4141056 Replicon chromosome
Accession NZ_CP125299
Organism Pseudalkalibacillus hwajinpoensis strain MABIK MI00000821

Toxin (Protein)


Gene name pemK Uniprot ID A0A0J6CT91
Locus tag QL286_RS20915 Protein ID WP_048312992.1
Coordinates 4140417..4140767 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A4U1MBT2
Locus tag QL286_RS20920 Protein ID WP_048312993.1
Coordinates 4140772..4141056 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QL286_RS20880 4135875..4136666 - 792 WP_194222493.1 RNA polymerase sigma factor SigB -
QL286_RS20885 4136635..4137114 - 480 WP_273853861.1 anti-sigma B factor RsbW -
QL286_RS20890 4137114..4137443 - 330 WP_194222494.1 STAS domain-containing protein -
QL286_RS20895 4137518..4138528 - 1011 WP_194222495.1 PP2C family protein-serine/threonine phosphatase -
QL286_RS20900 4138544..4138945 - 402 WP_194222496.1 anti-sigma regulatory factor -
QL286_RS20905 4138949..4139305 - 357 WP_194222497.1 STAS domain-containing protein -
QL286_RS20910 4139318..4140139 - 822 WP_194222498.1 STAS domain-containing protein -
QL286_RS20915 4140417..4140767 - 351 WP_048312992.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QL286_RS20920 4140772..4141056 - 285 WP_048312993.1 CopG family ribbon-helix-helix protein Antitoxin
QL286_RS20925 4141185..4142351 - 1167 WP_283153176.1 alanine racemase -
QL286_RS20930 4142643..4143647 - 1005 WP_242057453.1 outer membrane lipoprotein carrier protein LolA -
QL286_RS20935 4143708..4145240 - 1533 WP_283153177.1 NAD(P)H-hydrate dehydratase -
QL286_RS20940 4145298..4145657 - 360 WP_283153178.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13002.09 Da        Isoelectric Point: 6.4695

>T281973 WP_048312992.1 NZ_CP125299:c4140767-4140417 [Pseudalkalibacillus hwajinpoensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDEGMMQRVQEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10878.47 Da        Isoelectric Point: 5.1695

>AT281973 WP_048312993.1 NZ_CP125299:c4141056-4140772 [Pseudalkalibacillus hwajinpoensis]
MFVSEANKKSIVVTLPQHILNEVDGIIQQEQLDRNEFISQATTMYIRERKKRQIRDAMRQGYMEMAKINLNLAAEAFLVE
EEAEHTVDRLVSGV

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J6CT91

Antitoxin

Source ID Structure
AlphaFold DB A0A4U1MBT2

References