Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1582446..1583114 Replicon chromosome
Accession NZ_CP125291
Organism Streptococcus pneumoniae strain 105_Kz

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag QL280_RS07970 Protein ID WP_001132284.1
Coordinates 1582935..1583114 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag QL280_RS07965 Protein ID WP_000961810.1
Coordinates 1582446..1582898 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QL280_RS07940 (QL280_07940) 1578338..1579081 - 744 WP_001188212.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
QL280_RS07945 (QL280_07945) 1579083..1580033 - 951 WP_000451152.1 50S ribosomal protein L11 methyltransferase -
QL280_RS07950 (QL280_07950) 1580169..1580597 - 429 WP_000418174.1 NUDIX hydrolase -
QL280_RS07955 (QL280_07955) 1580578..1581666 - 1089 WP_000719713.1 site-2 protease family protein -
QL280_RS07960 (QL280_07960) 1581685..1582155 - 471 WP_000257086.1 DUF3013 family protein -
QL280_RS07965 (QL280_07965) 1582446..1582898 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QL280_RS07970 (QL280_07970) 1582935..1583114 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
QL280_RS07975 (QL280_07975) 1583251..1583430 - 180 WP_001048906.1 hypothetical protein -
QL280_RS07980 (QL280_07980) 1583595..1583816 - 222 WP_000425689.1 hypothetical protein -
QL280_RS07985 (QL280_07985) 1584108..1585379 + 1272 WP_001113212.1 replication-associated recombination protein A -
QL280_RS07995 (QL280_07995) 1585924..1587243 - 1320 WP_000502556.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T281966 WP_001132284.1 NZ_CP125291:c1583114-1582935 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT281966 WP_000961810.1 NZ_CP125291:c1582898-1582446 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References