Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1094757..1095255 Replicon chromosome
Accession NZ_CP125291
Organism Streptococcus pneumoniae strain 105_Kz

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag QL280_RS05450 Protein ID WP_001809704.1
Coordinates 1094757..1095011 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag QL280_RS05455 Protein ID WP_000208080.1
Coordinates 1095013..1095255 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QL280_RS05435 (QL280_05435) 1090018..1092486 - 2469 WP_001152992.1 DNA gyrase subunit A -
QL280_RS05440 (QL280_05440) 1092680..1093666 + 987 WP_000204727.1 L-lactate dehydrogenase -
QL280_RS05445 (QL280_05445) 1094015..1094710 - 696 WP_000731162.1 potassium channel family protein -
QL280_RS05450 (QL280_05450) 1094757..1095011 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QL280_RS05455 (QL280_05455) 1095013..1095255 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
QL280_RS05460 (QL280_05460) 1095346..1096155 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
QL280_RS05465 (QL280_05465) 1096157..1097506 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
QL280_RS05470 (QL280_05470) 1097499..1098203 - 705 WP_000722076.1 response regulator YycF -
QL280_RS05475 (QL280_05475) 1098258..1099433 - 1176 WP_000886153.1 A/G-specific adenine glycosylase -
QL280_RS05480 (QL280_05480) 1099530..1099655 + 126 WP_001818232.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T281964 WP_001809704.1 NZ_CP125291:c1095011-1094757 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT281964 WP_000208080.1 NZ_CP125291:c1095255-1095013 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References