Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1245664..1246581 Replicon chromosome
Accession NZ_CP125289
Organism Bacillus velezensis strain SF334

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag QLX65_RS06570 Protein ID WP_003154806.1
Coordinates 1245835..1246581 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QLX65_RS06565 Protein ID WP_003154807.1
Coordinates 1245664..1245834 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX65_RS06525 (QLX65_06525) 1240896..1242518 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
QLX65_RS06530 (QLX65_06530) 1242531..1242902 + 372 WP_014304856.1 XkdW family protein -
QLX65_RS06535 (QLX65_06535) 1242908..1243105 + 198 WP_003154819.1 XkdX family protein -
QLX65_RS06540 (QLX65_06540) 1243162..1243923 + 762 WP_024085194.1 hypothetical protein -
QLX65_RS06545 (QLX65_06545) 1243975..1244238 + 264 WP_032866112.1 hemolysin XhlA family protein -
QLX65_RS06550 (QLX65_06550) 1244252..1244515 + 264 WP_025851790.1 phage holin -
QLX65_RS06555 (QLX65_06555) 1244529..1245407 + 879 WP_025851788.1 N-acetylmuramoyl-L-alanine amidase -
QLX65_RS06560 (QLX65_06560) 1245442..1245567 - 126 WP_236550210.1 hypothetical protein -
QLX65_RS06565 (QLX65_06565) 1245664..1245834 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QLX65_RS06570 (QLX65_06570) 1245835..1246581 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QLX65_RS06575 (QLX65_06575) 1246685..1247683 - 999 WP_003154805.1 inorganic phosphate transporter -
QLX65_RS06580 (QLX65_06580) 1247696..1248313 - 618 WP_003154804.1 DUF47 domain-containing protein -
QLX65_RS06585 (QLX65_06585) 1248599..1249915 - 1317 WP_044053130.1 amino acid permease -
QLX65_RS06590 (QLX65_06590) 1250239..1251189 + 951 WP_014304860.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T281962 WP_003154806.1 NZ_CP125289:c1246581-1245835 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT281962 WP_003154807.1 NZ_CP125289:c1245834-1245664 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References