Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4848964..4849572 Replicon chromosome
Accession NZ_CP125288
Organism Pseudomonas aeruginosa strain SF416

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag QLX61_RS22360 Protein ID WP_023090047.1
Coordinates 4848964..4849311 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag QLX61_RS22365 Protein ID WP_003114155.1
Coordinates 4849321..4849572 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX61_RS22330 (QLX61_22325) 4844383..4844595 + 213 WP_003098360.1 cysteine-rich CWC family protein -
QLX61_RS22335 (QLX61_22330) 4844595..4845287 + 693 WP_023084583.1 16S rRNA pseudouridine(516) synthase -
QLX61_RS22340 (QLX61_22335) 4845423..4846466 + 1044 WP_003098363.1 L,D-transpeptidase -
QLX61_RS22345 (QLX61_22340) 4846546..4847283 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
QLX61_RS22350 (QLX61_22345) 4847735..4848637 + 903 WP_023084584.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
QLX61_RS22360 (QLX61_22355) 4848964..4849311 - 348 WP_023090047.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLX61_RS22365 (QLX61_22360) 4849321..4849572 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QLX61_RS22370 (QLX61_22365) 4849785..4850767 - 983 Protein_4425 tyrosine-type recombinase/integrase -
QLX61_RS22375 (QLX61_22370) 4850767..4852059 - 1293 WP_023090049.1 hypothetical protein -
QLX61_RS22380 (QLX61_22375) 4852697..4853086 - 390 WP_034053350.1 hypothetical protein -
QLX61_RS22385 (QLX61_22380) 4853079..4853294 - 216 WP_023090052.1 hypothetical protein -
QLX61_RS22390 (QLX61_22385) 4853317..4853532 - 216 WP_023090053.1 hypothetical protein -
QLX61_RS22395 (QLX61_22390) 4853684..4853929 + 246 WP_228380994.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4848814..4858792 9978


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12923.74 Da        Isoelectric Point: 4.5143

>T281959 WP_023090047.1 NZ_CP125288:c4849311-4848964 [Pseudomonas aeruginosa]
MTQVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPISQQASLLGVLSYRELNTGPYRIFY
ELHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIG

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT281959 WP_003114155.1 NZ_CP125288:c4849572-4849321 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References