281957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4527637..4528894 Replicon chromosome
Accession NZ_CP125288
Organism Pseudomonas aeruginosa strain SF416

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QLX61_RS20765 Protein ID WP_003449003.1
Coordinates 4527637..4528392 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QLX61_RS20770 Protein ID WP_003086329.1
Coordinates 4528526..4528894 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX61_RS20755 (QLX61_20750) 4522810..4525353 + 2544 WP_283000708.1 acyl-homoserine-lactone acylase QuiP -
QLX61_RS20760 (QLX61_20755) 4525508..4526869 - 1362 WP_003081943.1 DNA recombination protein RmuC -
QLX61_RS20765 (QLX61_20760) 4527637..4528392 - 756 WP_003449003.1 RES family NAD+ phosphorylase Toxin
QLX61_RS20770 (QLX61_20765) 4528526..4528894 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QLX61_RS20775 (QLX61_20770) 4528967..4530253 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
QLX61_RS20780 (QLX61_20775) 4530309..4531802 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QLX61_RS20785 (QLX61_20780) 4531977..4532453 + 477 WP_003112531.1 hypothetical protein -
QLX61_RS20790 (QLX61_20785) 4532456..4532731 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28292.45 Da        Isoelectric Point: 7.7294

>T281957 WP_003449003.1 NZ_CP125288:c4528392-4527637 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281957 WP_003086329.1 NZ_CP125288:c4528894-4528526 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References