Detailed information of TA system TA281956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1850973..1852481
• Replicon: chromosome
• Accession: NZ_CP125288
• Organism: Pseudomonas aeruginosa strain SF416

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QLX61_RS08605
• Protein ID: WP_012613851.1
• Coordinates: 1850973..1851560 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: QLX61_RS08610
• Protein ID: WP_012613852.1
• Coordinates: 1851627..1852481 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLX61_RS08600 (QLX61_08600)	1847228..1850707	-	3480	WP_023115144.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
QLX61_RS08605 (QLX61_08605)	1850973..1851560	+	588	WP_012613851.1	GNAT family protein	Toxin
QLX61_RS08610 (QLX61_08610)	1851627..1852481	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
QLX61_RS08615 (QLX61_08615)	1852578..1854743	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
QLX61_RS08620 (QLX61_08620)	1854918..1856792	+	1875	WP_003117607.1	MFS transporter	-
QLX61_RS08625 (QLX61_08625)	1856853..1857062	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T281956 WP_012613851.1 NZ_CP125288:1850973-1851560 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT281956 WP_012613852.1 NZ_CP125288:1851627-1852481 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp