281955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 164077..164582 Replicon chromosome
Accession NZ_CP125288
Organism Pseudomonas aeruginosa strain SF416

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QLX61_RS00740 Protein ID WP_023090221.1
Coordinates 164077..164358 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QLX61_RS00745 Protein ID WP_003083775.1
Coordinates 164355..164582 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX61_RS00715 (QLX61_00715) 159328..160677 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
QLX61_RS00720 (QLX61_00720) 160726..161412 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QLX61_RS00725 (QLX61_00725) 161513..162247 + 735 WP_023090219.1 GntR family transcriptional regulator -
QLX61_RS00730 (QLX61_00730) 162427..162837 + 411 WP_003110659.1 aegerolysin family protein -
QLX61_RS00735 (QLX61_00735) 162869..163777 - 909 WP_003083769.1 LysR family transcriptional regulator -
QLX61_RS00740 (QLX61_00740) 164077..164358 - 282 WP_023090221.1 type II toxin-antitoxin system toxin ParE Toxin
QLX61_RS00745 (QLX61_00745) 164355..164582 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QLX61_RS00750 (QLX61_00750) 164757..165377 - 621 WP_003101226.1 hypothetical protein -
QLX61_RS00755 (QLX61_00755) 165478..165978 + 501 WP_003101228.1 LEA type 2 family protein -
QLX61_RS00760 (QLX61_00760) 166051..166392 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QLX61_RS00765 (QLX61_00765) 166474..167901 - 1428 WP_003083784.1 GABA permease -
QLX61_RS00770 (QLX61_00770) 168070..169563 - 1494 WP_126584470.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10463.18 Da        Isoelectric Point: 9.6558

>T281955 WP_023090221.1 NZ_CP125288:c164358-164077 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVADQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281955 WP_003083775.1 NZ_CP125288:c164582-164355 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References