281954

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1236292..1237209 Replicon chromosome
Accession NZ_CP125283
Organism Bacillus velezensis strain IFST-221

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag QLX50_RS06470 Protein ID WP_007407256.1
Coordinates 1236463..1237209 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QLX50_RS06465 Protein ID WP_003154807.1
Coordinates 1236292..1236462 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX50_RS06425 (QLX50_06425) 1231504..1233093 + 1590 WP_044802869.1 hypothetical protein -
QLX50_RS06430 (QLX50_06430) 1233106..1233531 + 426 WP_083061813.1 hypothetical protein -
QLX50_RS06435 (QLX50_06435) 1233536..1233733 + 198 WP_007610833.1 XkdX family protein -
QLX50_RS06440 (QLX50_06440) 1233790..1234551 + 762 WP_044802871.1 hypothetical protein -
QLX50_RS06445 (QLX50_06445) 1234603..1234866 + 264 WP_003154815.1 hemolysin XhlA family protein -
QLX50_RS06450 (QLX50_06450) 1234880..1235143 + 264 WP_003154813.1 phage holin -
QLX50_RS06455 (QLX50_06455) 1235157..1236035 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
QLX50_RS06460 (QLX50_06460) 1236070..1236195 - 126 WP_003154809.1 hypothetical protein -
QLX50_RS06465 (QLX50_06465) 1236292..1236462 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QLX50_RS06470 (QLX50_06470) 1236463..1237209 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QLX50_RS06475 (QLX50_06475) 1237316..1238314 - 999 WP_044802872.1 inorganic phosphate transporter -
QLX50_RS06480 (QLX50_06480) 1238327..1238944 - 618 WP_032874614.1 DUF47 domain-containing protein -
QLX50_RS06485 (QLX50_06485) 1239231..1240547 - 1317 WP_044802873.1 amino acid permease -
QLX50_RS06490 (QLX50_06490) 1240870..1241820 + 951 WP_007610844.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1202675..1245437 42762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T281954 WP_007407256.1 NZ_CP125283:c1237209-1236463 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT281954 WP_003154807.1 NZ_CP125283:c1236462-1236292 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References