Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1296272..1297189 Replicon chromosome
Accession NZ_CP125279
Organism Bacillus velezensis strain FLU-1

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag QLH34_RS06930 Protein ID WP_032866111.1
Coordinates 1296443..1297189 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QLH34_RS06925 Protein ID WP_003154807.1
Coordinates 1296272..1296442 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLH34_RS06890 (1291484) 1291484..1293073 + 1590 WP_205164551.1 hypothetical protein -
QLH34_RS06895 (1293086) 1293086..1293511 + 426 WP_050498185.1 hypothetical protein -
QLH34_RS06900 (1293516) 1293516..1293713 + 198 WP_007610833.1 XkdX family protein -
QLH34_RS06905 (1293770) 1293770..1294531 + 762 WP_020955694.1 hypothetical protein -
QLH34_RS06910 (1294583) 1294583..1294846 + 264 WP_003154815.1 hemolysin XhlA family protein -
QLH34_RS06915 (1294860) 1294860..1295123 + 264 WP_003154813.1 phage holin -
QLH34_RS06920 (1295137) 1295137..1296015 + 879 WP_020955695.1 N-acetylmuramoyl-L-alanine amidase -
QLH34_RS06925 (1296272) 1296272..1296442 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QLH34_RS06930 (1296443) 1296443..1297189 - 747 WP_032866111.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QLH34_RS06935 (1297293) 1297293..1298291 - 999 WP_020955696.1 inorganic phosphate transporter -
QLH34_RS06940 (1298304) 1298304..1298921 - 618 WP_003154804.1 DUF47 domain-containing protein -
QLH34_RS06945 (1299207) 1299207..1300523 - 1317 WP_007407254.1 amino acid permease -
QLH34_RS06950 (1300846) 1300846..1301796 + 951 WP_218791607.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1261268..1305446 44178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29095.60 Da        Isoelectric Point: 4.7755

>T281952 WP_032866111.1 NZ_CP125279:c1297189-1296443 [Bacillus velezensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT281952 WP_003154807.1 NZ_CP125279:c1296442-1296272 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References