281946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5666..6254 Replicon plasmid unnamed
Accession NZ_CP125224
Organism Acinetobacter baumannii strain EGA65

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag QMA76_RS18845 Protein ID WP_000438827.1
Coordinates 5666..5953 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag QMA76_RS18850 Protein ID WP_001983304.1
Coordinates 5940..6254 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMA76_RS18815 (QMA76_18815) 944..1519 + 576 WP_001096611.1 plasmid replication DNA-binding protein -
QMA76_RS18820 (QMA76_18820) 1541..1684 + 144 WP_000734097.1 hypothetical protein -
QMA76_RS18825 (QMA76_18825) 1991..2266 + 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
QMA76_RS18830 (QMA76_18830) 2288..3397 + 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
QMA76_RS18835 (QMA76_18835) 3450..3848 + 399 WP_000235176.1 VOC family protein -
QMA76_RS18840 (QMA76_18840) 4322..5155 + 834 WP_000439570.1 S-formylglutathione hydrolase -
QMA76_RS18845 (QMA76_18845) 5666..5953 + 288 WP_000438827.1 BrnT family toxin Toxin
QMA76_RS18850 (QMA76_18850) 5940..6254 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
QMA76_RS18855 (QMA76_18855) 6382..8793 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
QMA76_RS18860 (QMA76_18860) 9098..9559 + 462 WP_000761346.1 DIP1984 family protein -
QMA76_RS18865 (QMA76_18865) 9880..10413 - 534 WP_000965055.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14639 14639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T281946 WP_000438827.1 NZ_CP125224:5666-5953 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT281946 WP_001983304.1 NZ_CP125224:5940-6254 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References