Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179310..4180091 Replicon chromosome
Accession NZ_CP125220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain sm140

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag QK897_RS20460 Protein ID WP_000626100.1
Coordinates 4179310..4179801 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag QK897_RS20465 Protein ID WP_001110452.1
Coordinates 4179798..4180091 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QK897_RS20425 (4174770) 4174770..4175117 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
QK897_RS20430 (4175093) 4175093..4176796 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
QK897_RS20435 (4176833) 4176833..4177408 + 576 WP_001188509.1 transcriptional regulator -
QK897_RS20445 (4177679) 4177679..4177753 - 75 Protein_3995 helix-turn-helix domain-containing protein -
QK897_RS20450 (4178133) 4178133..4178210 + 78 Protein_3996 porin family protein -
QK897_RS20455 (4178310) 4178310..4179062 + 753 WP_000842433.1 non-specific acid phosphatase -
QK897_RS20460 (4179310) 4179310..4179801 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
QK897_RS20465 (4179798) 4179798..4180091 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
QK897_RS20470 (4180408) 4180408..4180629 + 222 WP_001576552.1 hypothetical protein -
QK897_RS20475 (4180895) 4180895..4181770 + 876 WP_000921676.1 AraC family transcriptional regulator -
QK897_RS20480 (4181767) 4181767..4182054 + 288 WP_001541332.1 transcriptional regulator RtsB -
QK897_RS20485 (4182047) 4182047..4182355 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
QK897_RS20490 (4182354) 4182354..4182602 + 249 Protein_4004 Ig-like domain-containing protein -
QK897_RS20495 (4182714) 4182714..4182845 + 132 Protein_4005 hypothetical protein -
QK897_RS20500 (4183139) 4183139..4184044 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T281939 WP_000626100.1 NZ_CP125220:c4179801-4179310 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT281939 WP_001110452.1 NZ_CP125220:c4180091-4179798 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References