Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3411500..3412120 Replicon chromosome
Accession NZ_CP125220
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain sm140

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QK897_RS16815 Protein ID WP_001280991.1
Coordinates 3411902..3412120 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QK897_RS16810 Protein ID WP_000344807.1
Coordinates 3411500..3411874 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QK897_RS16800 (3406639) 3406639..3407832 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QK897_RS16805 (3407855) 3407855..3411004 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QK897_RS16810 (3411500) 3411500..3411874 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QK897_RS16815 (3411902) 3411902..3412120 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QK897_RS16820 (3412299) 3412299..3412850 + 552 WP_001278793.1 maltose O-acetyltransferase -
QK897_RS16825 (3412968) 3412968..3413438 + 471 WP_000136183.1 YlaC family protein -
QK897_RS16830 (3413494) 3413494..3413634 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QK897_RS16835 (3413640) 3413640..3413900 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QK897_RS16840 (3414125) 3414125..3415675 + 1551 WP_000213140.1 EAL domain-containing protein -
QK897_RS16850 (3415906) 3415906..3416295 + 390 WP_000961287.1 MGMT family protein -
QK897_RS16855 (3416328) 3416328..3416897 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T281933 WP_001280991.1 NZ_CP125220:3411902-3412120 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT281933 WP_000344807.1 NZ_CP125220:3411500-3411874 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References