Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1068..1648 Replicon plasmid pBAK085d
Accession NZ_CP125092
Organism Klebsiella pneumoniae strain BAK085

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag QJS47_RS27785 Protein ID WP_001136729.1
Coordinates 1334..1648 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QJS47_RS27780 Protein ID WP_000093040.1
Coordinates 1068..1346 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS47_RS27770 (QJS47_27770) 140..511 + 372 WP_001237044.1 cell envelope integrity protein TolA -
QJS47_RS27775 (QJS47_27775) 508..726 + 219 WP_002193751.1 TonB family protein -
QJS47_RS27780 (QJS47_27780) 1068..1346 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QJS47_RS27785 (QJS47_27785) 1334..1648 + 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJS47_RS27790 (QJS47_27790) 1812..2240 + 429 WP_001140599.1 hypothetical protein -
QJS47_RS27795 (QJS47_27795) 2266..2445 + 180 WP_065521055.1 Rop family plasmid primer RNA-binding protein -
QJS47_RS27800 (QJS47_27800) 2473..3003 - 531 WP_065521056.1 hypothetical protein -
QJS47_RS27805 (QJS47_27805) 3010..3741 - 732 WP_032448355.1 MobC family replication-relaxation protein -
QJS47_RS27810 (QJS47_27810) 3741..5702 - 1962 WP_202179206.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10078 10078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T281914 WP_001136729.1 NZ_CP125092:1334-1648 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT281914 WP_000093040.1 NZ_CP125092:1068-1346 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References