Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4938786..4940467 Replicon chromosome
Accession NZ_CP125088
Organism Klebsiella pneumoniae strain BAK085

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QJS47_RS24400 Protein ID WP_002885155.1
Coordinates 4938786..4939703 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag QJS47_RS24405 Protein ID WP_004151732.1
Coordinates 4939709..4940467 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS47_RS24380 (QJS47_24380) 4934092..4935612 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QJS47_RS24385 (QJS47_24385) 4935609..4936607 + 999 WP_002885172.1 ribose ABC transporter permease -
QJS47_RS24390 (QJS47_24390) 4936638..4937579 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QJS47_RS24395 (QJS47_24395) 4937654..4938661 + 1008 WP_004151731.1 carbohydrate kinase family protein -
QJS47_RS24400 (QJS47_24400) 4938786..4939703 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QJS47_RS24405 (QJS47_24405) 4939709..4940467 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QJS47_RS24410 (QJS47_24410) 4940553..4941281 - 729 WP_002885152.1 response regulator transcription factor -
QJS47_RS24415 (QJS47_24415) 4941554..4943701 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
QJS47_RS24420 (QJS47_24420) 4943931..4944617 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T281910 WP_002885155.1 NZ_CP125088:c4939703-4938786 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT281910 WP_004151732.1 NZ_CP125088:c4940467-4939709 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References