Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5096501..5097158 Replicon chromosome
Accession NZ_CP125086
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QFB74_RS25765 Protein ID WP_002916310.1
Coordinates 5096748..5097158 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QFB74_RS25760 Protein ID WP_002916312.1
Coordinates 5096501..5096767 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB74_RS25735 (5091709) 5091709..5093142 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QFB74_RS25740 (5093261) 5093261..5093989 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QFB74_RS25745 (5094039) 5094039..5094350 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QFB74_RS25750 (5094514) 5094514..5095173 + 660 WP_002916317.1 hemolysin III family protein -
QFB74_RS25755 (5095272) 5095272..5096255 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
QFB74_RS25760 (5096501) 5096501..5096767 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QFB74_RS25765 (5096748) 5096748..5097158 + 411 WP_002916310.1 protein YgfX Toxin
QFB74_RS25770 (5097165) 5097165..5097686 - 522 WP_002916308.1 flavodoxin FldB -
QFB74_RS25775 (5097787) 5097787..5098683 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QFB74_RS25780 (5098706) 5098706..5099419 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QFB74_RS25785 (5099425) 5099425..5101158 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281898 WP_002916310.1 NZ_CP125086:5096748-5097158 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281898 WP_002916312.1 NZ_CP125086:5096501-5096767 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References