Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4220870..4221495 Replicon chromosome
Accession NZ_CP125086
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP2

Toxin (Protein)


Gene name vapC Uniprot ID A0A330XB05
Locus tag QFB74_RS21445 Protein ID WP_012737091.1
Coordinates 4220870..4221253 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QFB74_RS21450 Protein ID WP_004150355.1
Coordinates 4221253..4221495 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB74_RS21430 (4218236) 4218236..4219138 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QFB74_RS21435 (4219135) 4219135..4219770 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QFB74_RS21440 (4219767) 4219767..4220696 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QFB74_RS21445 (4220870) 4220870..4221253 - 384 WP_012737091.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB74_RS21450 (4221253) 4221253..4221495 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QFB74_RS21455 (4221700) 4221700..4222617 + 918 WP_012737090.1 alpha/beta hydrolase -
QFB74_RS21460 (4222631) 4222631..4223572 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QFB74_RS21465 (4223617) 4223617..4224054 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QFB74_RS21470 (4224051) 4224051..4224911 - 861 WP_004146232.1 virulence factor BrkB family protein -
QFB74_RS21475 (4224905) 4224905..4225504 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14266.53 Da        Isoelectric Point: 7.2771

>T281895 WP_012737091.1 NZ_CP125086:c4221253-4220870 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKGFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281895 WP_004150355.1 NZ_CP125086:c4221495-4221253 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330XB05

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References