Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3751196..3751712 Replicon chromosome
Accession NZ_CP125086
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QFB74_RS19205 Protein ID WP_004178374.1
Coordinates 3751196..3751480 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QFB74_RS19210 Protein ID WP_002886901.1
Coordinates 3751470..3751712 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB74_RS19180 (3746592) 3746592..3746900 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
QFB74_RS19185 (3746985) 3746985..3747158 + 174 WP_041169004.1 hypothetical protein -
QFB74_RS19190 (3747161) 3747161..3747904 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QFB74_RS19195 (3748261) 3748261..3750399 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QFB74_RS19200 (3750728) 3750728..3751192 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QFB74_RS19205 (3751196) 3751196..3751480 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB74_RS19210 (3751470) 3751470..3751712 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QFB74_RS19215 (3751790) 3751790..3753700 - 1911 WP_012737231.1 PRD domain-containing protein -
QFB74_RS19220 (3753723) 3753723..3754877 - 1155 WP_012737230.1 lactonase family protein -
QFB74_RS19225 (3754944) 3754944..3755684 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T281894 WP_004178374.1 NZ_CP125086:c3751480-3751196 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281894 WP_002886901.1 NZ_CP125086:c3751712-3751470 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References