Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3585287..3586097 Replicon chromosome
Accession NZ_CP125086
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP2

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag QFB74_RS18475 Protein ID WP_014908042.1
Coordinates 3585287..3585820 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QFB74_RS18480 Protein ID WP_002887278.1
Coordinates 3585831..3586097 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB74_RS18470 (3584118) 3584118..3585239 + 1122 WP_012737335.1 cupin domain-containing protein -
QFB74_RS18475 (3585287) 3585287..3585820 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
QFB74_RS18480 (3585831) 3585831..3586097 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QFB74_RS18485 (3586200) 3586200..3587633 - 1434 WP_014908043.1 Cu(+)/Ag(+) sensor histidine kinase -
QFB74_RS18490 (3587623) 3587623..3588306 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QFB74_RS18495 (3588478) 3588478..3589863 + 1386 WP_012737332.1 efflux transporter outer membrane subunit -
QFB74_RS18500 (3589881) 3589881..3590225 + 345 WP_012737331.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T281893 WP_014908042.1 NZ_CP125086:c3585820-3585287 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT281893 WP_002887278.1 NZ_CP125086:c3586097-3585831 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References