Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1618053..1619641 Replicon chromosome
Accession NZ_CP125086
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP2

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag QFB74_RS09070 Protein ID WP_014907613.1
Coordinates 1618053..1619375 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QFB74_RS09075 Protein ID WP_002904790.1
Coordinates 1619375..1619641 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB74_RS09055 (1613109) 1613109..1615610 + 2502 WP_014907611.1 fimbria/pilus outer membrane usher protein -
QFB74_RS09060 (1615598) 1615598..1616602 + 1005 WP_014907612.1 fimbrial protein -
QFB74_RS09065 (1616744) 1616744..1618036 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QFB74_RS09070 (1618053) 1618053..1619375 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
QFB74_RS09075 (1619375) 1619375..1619641 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QFB74_RS09080 (1619879) 1619879..1620205 - 327 WP_004215084.1 hydroxyisourate hydrolase -
QFB74_RS09085 (1620202) 1620202..1620702 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QFB74_RS09090 (1620680) 1620680..1622059 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QFB74_RS09095 (1622405) 1622405..1623559 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QFB74_RS09100 (1623540) 1623540..1624463 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T281891 WP_014907613.1 NZ_CP125086:c1619375-1618053 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT281891 WP_002904790.1 NZ_CP125086:c1619641-1619375 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References