Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 51209..51852 Replicon plasmid p_IncFIA_HI1
Accession NZ_CP125084
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QFB57_RS26580 Protein ID WP_001044768.1
Coordinates 51209..51625 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QFB57_RS26585 Protein ID WP_001261287.1
Coordinates 51622..51852 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS26545 46303..46557 - 255 WP_016528790.1 hypothetical protein -
QFB57_RS26550 46633..46890 - 258 WP_004098928.1 hypothetical protein -
QFB57_RS26555 46939..47142 - 204 WP_004150739.1 HHA domain-containing protein -
QFB57_RS26560 47203..47697 - 495 WP_016528789.1 hypothetical protein -
QFB57_RS26565 47728..48294 - 567 WP_009654312.1 hypothetical protein -
QFB57_RS26570 48291..48554 - 264 WP_009310051.1 hypothetical protein -
QFB57_RS26575 48909..51047 + 2139 WP_000350635.1 AAA family ATPase -
QFB57_RS26580 51209..51625 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QFB57_RS26585 51622..51852 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QFB57_RS26590 52158..55277 + 3120 WP_032446663.1 hypothetical protein -
QFB57_RS26595 55540..56673 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - clbI / basG 1..95433 95433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T281882 WP_001044768.1 NZ_CP125084:c51625-51209 [Klebsiella pneumoniae subsp. pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT281882 WP_001261287.1 NZ_CP125084:c51852-51622 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References