Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4824755..4825412 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QFB57_RS24160 Protein ID WP_002916310.1
Coordinates 4825002..4825412 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QFB57_RS24155 Protein ID WP_002916312.1
Coordinates 4824755..4825021 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS24130 (4819911) 4819911..4821344 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QFB57_RS24135 (4821463) 4821463..4822191 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QFB57_RS24140 (4822241) 4822241..4822552 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QFB57_RS24145 (4822716) 4822716..4823375 + 660 WP_002916317.1 hemolysin III family protein -
QFB57_RS24150 (4823526) 4823526..4824509 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
QFB57_RS24155 (4824755) 4824755..4825021 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QFB57_RS24160 (4825002) 4825002..4825412 + 411 WP_002916310.1 protein YgfX Toxin
QFB57_RS24165 (4825419) 4825419..4825940 - 522 WP_004144730.1 flavodoxin FldB -
QFB57_RS24170 (4826041) 4826041..4826937 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QFB57_RS24175 (4826960) 4826960..4827673 + 714 WP_282822445.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QFB57_RS24180 (4827679) 4827679..4829412 + 1734 WP_032445465.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281881 WP_002916310.1 NZ_CP125083:4825002-4825412 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281881 WP_002916312.1 NZ_CP125083:4824755-4825021 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References