Detailed information of TA system TA281875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 3484355..3484871
• Replicon: chromosome
• Accession: NZ_CP125083
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: QFB57_RS17585
• Protein ID: WP_032446557.1
• Coordinates: 3484355..3484639 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: QFB57_RS17590
• Protein ID: WP_002886901.1
• Coordinates: 3484629..3484871 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11110.98 Da
• Isoelectric Point: 10.3787

>T281875 WP_032446557.1 NZ_CP125083:c3484639-3484355 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHLANKRL

Nucleotide

• Length: 285 bp

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT281875 WP_002886901.1 NZ_CP125083:c3484871-3484629 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0