281875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3484355..3484871 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QFB57_RS17585 Protein ID WP_032446557.1
Coordinates 3484355..3484639 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QFB57_RS17590 Protein ID WP_002886901.1
Coordinates 3484629..3484871 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS17560 (3479751) 3479751..3480059 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
QFB57_RS17565 (3480144) 3480144..3480317 + 174 WP_002886906.1 hypothetical protein -
QFB57_RS17570 (3480320) 3480320..3481063 + 744 WP_032446555.1 MurR/RpiR family transcriptional regulator -
QFB57_RS17575 (3481420) 3481420..3483558 + 2139 WP_032446556.1 anaerobic ribonucleoside-triphosphate reductase -
QFB57_RS17580 (3483887) 3483887..3484351 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QFB57_RS17585 (3484355) 3484355..3484639 - 285 WP_032446557.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB57_RS17590 (3484629) 3484629..3484871 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QFB57_RS17595 (3484949) 3484949..3486859 - 1911 WP_004152270.1 PRD domain-containing protein -
QFB57_RS17600 (3486882) 3486882..3488036 - 1155 WP_002886900.1 lactonase family protein -
QFB57_RS17605 (3488103) 3488103..3488843 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11110.98 Da        Isoelectric Point: 10.3787

>T281875 WP_032446557.1 NZ_CP125083:c3484639-3484355 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHLANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281875 WP_002886901.1 NZ_CP125083:c3484871-3484629 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References