Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3347915..3348725 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag QFB57_RS17050 Protein ID WP_004178461.1
Coordinates 3347915..3348448 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QFB57_RS17055 Protein ID WP_002887278.1
Coordinates 3348459..3348725 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS17045 (3346746) 3346746..3347867 + 1122 WP_009309849.1 cupin domain-containing protein -
QFB57_RS17050 (3347915) 3347915..3348448 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
QFB57_RS17055 (3348459) 3348459..3348725 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QFB57_RS17060 (3348828) 3348828..3350261 - 1434 WP_032446518.1 Cu(+)/Ag(+) sensor histidine kinase -
QFB57_RS17065 (3350251) 3350251..3350934 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QFB57_RS17070 (3351106) 3351106..3352488 + 1383 WP_032446519.1 efflux transporter outer membrane subunit -
QFB57_RS17075 (3352506) 3352506..3352850 + 345 WP_025987660.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T281873 WP_004178461.1 NZ_CP125083:c3348448-3347915 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT281873 WP_002887278.1 NZ_CP125083:c3348725-3348459 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References