Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1401243..1402831 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QFB57_RS07735 Protein ID WP_019705665.1
Coordinates 1401243..1402565 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QFB57_RS07740 Protein ID WP_002904790.1
Coordinates 1402565..1402831 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS07720 (1396292) 1396292..1398793 + 2502 WP_282822607.1 fimbria/pilus outer membrane usher protein -
QFB57_RS07725 (1398781) 1398781..1399792 + 1012 Protein_1308 fimbrial protein -
QFB57_RS07730 (1399934) 1399934..1401226 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QFB57_RS07735 (1401243) 1401243..1402565 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
QFB57_RS07740 (1402565) 1402565..1402831 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QFB57_RS07745 (1403218) 1403218..1403544 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QFB57_RS07750 (1403541) 1403541..1404041 - 501 WP_032446037.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QFB57_RS07755 (1404019) 1404019..1405398 - 1380 WP_032446036.1 nucleobase:cation symporter-2 family protein -
QFB57_RS07760 (1405744) 1405744..1406898 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QFB57_RS07765 (1406879) 1406879..1407610 - 732 WP_282822609.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T281870 WP_019705665.1 NZ_CP125083:c1402565-1401243 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT281870 WP_002904790.1 NZ_CP125083:c1402831-1402565 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References