Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1401243..1402831 | Replicon | chromosome |
Accession | NZ_CP125083 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain HVKP1 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | QFB57_RS07735 | Protein ID | WP_019705665.1 |
Coordinates | 1401243..1402565 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
Locus tag | QFB57_RS07740 | Protein ID | WP_002904790.1 |
Coordinates | 1402565..1402831 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QFB57_RS07720 (1396292) | 1396292..1398793 | + | 2502 | WP_282822607.1 | fimbria/pilus outer membrane usher protein | - |
QFB57_RS07725 (1398781) | 1398781..1399792 | + | 1012 | Protein_1308 | fimbrial protein | - |
QFB57_RS07730 (1399934) | 1399934..1401226 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
QFB57_RS07735 (1401243) | 1401243..1402565 | - | 1323 | WP_019705665.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
QFB57_RS07740 (1402565) | 1402565..1402831 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
QFB57_RS07745 (1403218) | 1403218..1403544 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
QFB57_RS07750 (1403541) | 1403541..1404041 | - | 501 | WP_032446037.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
QFB57_RS07755 (1404019) | 1404019..1405398 | - | 1380 | WP_032446036.1 | nucleobase:cation symporter-2 family protein | - |
QFB57_RS07760 (1405744) | 1405744..1406898 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
QFB57_RS07765 (1406879) | 1406879..1407610 | - | 732 | WP_282822609.1 | LysR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49155.46 Da Isoelectric Point: 7.5358
>T281870 WP_019705665.1 NZ_CP125083:c1402565-1401243 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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