281865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 139444..140195 Replicon plasmid p_IncFIB_K
Accession NZ_CP125081
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name ataT Uniprot ID W9BA31
Locus tag QFB57_RS00755 Protein ID WP_032104592.1
Coordinates 139444..139926 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID W9B1S8
Locus tag QFB57_RS00760 Protein ID WP_016529519.1
Coordinates 139917..140195 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS00725 135027..135479 + 453 WP_020948374.1 transcriptional repressor -
QFB57_RS00730 135627..136855 + 1229 WP_085956323.1 IS3 family transposase -
QFB57_RS00735 137240..137476 + 237 WP_016529523.1 hypothetical protein -
QFB57_RS00740 137571..137732 - 162 WP_223367960.1 bacteriocin immunity protein -
QFB57_RS00745 137832..138665 - 834 WP_012540133.1 GIY-YIG nuclease family protein -
QFB57_RS00750 139002..139406 - 405 WP_016529521.1 DUF2251 domain-containing protein -
QFB57_RS00755 139444..139926 - 483 WP_032104592.1 GNAT family N-acetyltransferase Toxin
QFB57_RS00760 139917..140195 - 279 WP_016529519.1 DUF1778 domain-containing protein Antitoxin
QFB57_RS00765 140503..141039 + 537 WP_032445791.1 hypothetical protein -
QFB57_RS00770 141423..142433 - 1011 WP_004152284.1 zinc-binding alcohol dehydrogenase family protein -
QFB57_RS00775 142776..142858 + 83 Protein_154 hypothetical protein -
QFB57_RS00780 142894..143976 + 1083 WP_016528990.1 DNA-binding transcriptional repressor LacI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - rmpA / iroN / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..154088 154088


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17781.73 Da        Isoelectric Point: 9.4946

>T281865 WP_032104592.1 NZ_CP125081:c139926-139444 [Klebsiella pneumoniae subsp. pneumoniae]
MGMRPPEPLTPEHNIAEFCCQDQVLSEWLKKKALKNHRTGISRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10708.23 Da        Isoelectric Point: 4.5156

>AT281865 WP_016529519.1 NZ_CP125081:c140195-139917 [Klebsiella pneumoniae subsp. pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDNQFNAFVEELDAPMTPERQAR
IDNLMSRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BA31

Antitoxin

Source ID Structure
AlphaFold DB W9B1S8

References