Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 80691..81601 | Replicon | plasmid p_IncFIB_K |
| Accession | NZ_CP125081 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain HVKP1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | QFB57_RS00430 | Protein ID | WP_004144067.1 |
| Coordinates | 80691..81161 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | W9B1L8 |
| Locus tag | QFB57_RS00435 | Protein ID | WP_016528982.1 |
| Coordinates | 81158..81601 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QFB57_RS00400 | 75799..76005 | - | 207 | Protein_79 | IS66 family transposase | - |
| QFB57_RS00405 | 76490..76648 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| QFB57_RS00410 | 77289..77456 | - | 168 | WP_162837823.1 | hypothetical protein | - |
| QFB57_RS00415 | 77942..78721 | + | 780 | WP_225932725.1 | Hok/Gef family protein | - |
| QFB57_RS00425 | 80320..80580 | + | 261 | WP_016528980.1 | hypothetical protein | - |
| QFB57_RS00430 | 80691..81161 | - | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| QFB57_RS00435 | 81158..81601 | - | 444 | WP_016528982.1 | DUF2384 domain-containing protein | Antitoxin |
| QFB57_RS00440 | 81702..82191 | - | 490 | Protein_87 | DUF4113 domain-containing protein | - |
| QFB57_RS00445 | 82300..82521 | - | 222 | WP_016528984.1 | DUF2188 domain-containing protein | - |
| QFB57_RS00450 | 82696..82821 | - | 126 | Protein_89 | Fe3+-citrate ABC transporter substrate-binding protein | - |
| QFB57_RS00455 | 82903..85029 | - | 2127 | WP_032446634.1 | TonB-dependent Fe(3+) dicitrate receptor FecA | - |
| QFB57_RS00460 | 85116..86069 | - | 954 | Protein_91 | ferric citrate uptake sigma factor regulator FecR | - |
| QFB57_RS00465 | 86066..86587 | - | 522 | WP_004213635.1 | ferric citrate uptake sigma factor FecI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | rmpA / iroN / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA | 1..154088 | 154088 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T281864 WP_004144067.1 NZ_CP125081:c81161-80691 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16494.83 Da Isoelectric Point: 10.2498
>AT281864 WP_016528982.1 NZ_CP125081:c81601-81158 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEIIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEIIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | W9B1L8 |