Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2109301..2109907 Replicon chromosome
Accession NZ_CP124967
Organism Agrobacterium tumefaciens strain O54/95

Toxin (Protein)


Gene name PumA Uniprot ID A0A822UZY8
Locus tag G6L90_RS10490 Protein ID WP_020011654.1
Coordinates 2109301..2109597 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A822V132
Locus tag G6L90_RS10495 Protein ID WP_060723677.1
Coordinates 2109602..2109907 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L90_RS10455 (G6L90_10455) 2104897..2105244 + 348 WP_004429958.1 antibiotic biosynthesis monooxygenase -
G6L90_RS10460 (G6L90_10460) 2105254..2105778 + 525 WP_112278475.1 heme utilization cystosolic carrier protein HutX -
G6L90_RS10465 (G6L90_10465) 2105962..2106351 + 390 WP_223564872.1 hypothetical protein -
G6L90_RS10470 (G6L90_10470) 2106503..2107042 + 540 WP_111792962.1 DUF2975 domain-containing protein -
G6L90_RS10475 (G6L90_10475) 2107052..2107294 + 243 WP_080866411.1 helix-turn-helix transcriptional regulator -
G6L90_RS10480 (G6L90_10480) 2107388..2108164 + 777 WP_020809374.1 YbaY family lipoprotein -
G6L90_RS10485 (G6L90_10485) 2108371..2109255 + 885 WP_004429922.1 formyltetrahydrofolate deformylase -
G6L90_RS10490 (G6L90_10490) 2109301..2109597 + 297 WP_020011654.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6L90_RS10495 (G6L90_10495) 2109602..2109907 + 306 WP_060723677.1 putative addiction module antidote protein Antitoxin
G6L90_RS10500 (G6L90_10500) 2109921..2111315 - 1395 WP_129565097.1 sensor histidine kinase -
G6L90_RS10505 (G6L90_10505) 2111312..2111992 - 681 WP_003491888.1 response regulator transcription factor -
G6L90_RS10510 (G6L90_10510) 2112073..2113140 + 1068 WP_223566790.1 ABC transporter substrate-binding protein -
G6L90_RS10515 (G6L90_10515) 2113586..2114530 + 945 WP_174069831.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10888.61 Da        Isoelectric Point: 10.2733

>T281860 WP_020011654.1 NZ_CP124967:2109301-2109597 [Agrobacterium tumefaciens]
MLTIRETSEFADWLAGLRDVQARARIARRIYRLADGNPGDVKPVGEGVSELRIDLGPGYRVYFVRHGDVVIILLCGGDKA
SQPRDIARAKKLARALKE

Download         Length: 297 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10576.90 Da        Isoelectric Point: 4.5580

>AT281860 WP_060723677.1 NZ_CP124967:2109602-2109907 [Agrobacterium tumefaciens]
MPLVTRDYDAARYLDSDEALAAYIADATESGDAQELAHALGVVARAKGMTDLSRQTGLPRQTLYKALSGEGNPELATIAK
VADALGYRLSLVAKPPADTAA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822UZY8

Antitoxin

Source ID Structure
AlphaFold DB A0A822V132

References