Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2118003..2119513 Replicon chromosome
Accession NZ_CP124964
Organism Agrobacterium fabacearum strain AF1/95

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag G6L16_RS23530 Protein ID WP_284180576.1
Coordinates 2118272..2119513 (+) Length 414 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag G6L16_RS23525 Protein ID WP_097099301.1
Coordinates 2118003..2118275 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L16_RS23490 (G6L16_023490) 2113935..2114321 - 387 WP_174004625.1 ester cyclase -
G6L16_RS23495 (G6L16_023495) 2114391..2115014 - 624 WP_174004627.1 histidine phosphatase family protein -
G6L16_RS23500 (G6L16_023500) 2115011..2115565 - 555 WP_174004629.1 AAA family ATPase -
G6L16_RS23505 (G6L16_023505) 2115752..2115991 - 240 WP_210201850.1 transcriptional regulator -
G6L16_RS23510 (G6L16_023510) 2116137..2116904 + 768 WP_174002541.1 hypothetical protein -
G6L16_RS23515 (G6L16_023515) 2117011..2117139 - 129 WP_272871219.1 hypothetical protein -
G6L16_RS23520 (G6L16_023520) 2117263..2117583 - 321 WP_174002540.1 hypothetical protein -
G6L16_RS23525 (G6L16_023525) 2118003..2118275 + 273 WP_097099301.1 helix-turn-helix domain-containing protein Antitoxin
G6L16_RS23530 (G6L16_023530) 2118272..2119513 + 1242 WP_284180576.1 type II toxin-antitoxin system HipA family toxin Toxin
G6L16_RS23535 (G6L16_023535) 2119894..2120313 + 420 WP_174005433.1 thermonuclease family protein -
G6L16_RS23540 (G6L16_023540) 2120526..2120903 + 378 WP_111801654.1 hypothetical protein -
G6L16_RS23545 (G6L16_023545) 2121401..2121925 + 525 Protein_1878 HEPN domain-containing protein -
G6L16_RS23550 (G6L16_023550) 2121951..2122160 + 210 WP_174005431.1 hypothetical protein -
G6L16_RS23555 (G6L16_023555) 2122311..2122466 - 156 Protein_1880 tetrahydrofolate dehydrogenase/cyclohydrolase catalytic domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 414 a.a.        Molecular weight: 45257.05 Da        Isoelectric Point: 7.3801

>T281854 WP_284180576.1 NZ_CP124964:2118272-2119513 [Agrobacterium fabacearum]
MTTIYYETLPVAHLSFEGEWRLDYDPGWEARRPAFPVSLTMPLRSGSVGAAKLLPWLANLLPETHLAEIGQRLKVSPQDI
VGLLAHIGRDTAGALSIGEPRKAGVNLQPVPDEQALERILNELPAKPFLVGERGVSMSLAGVQEKLPVFVEGSGRISVPV
DGTPSTHILKPDTKRLAGSVENEAFCLSLARACGLDAAEATIGVAGKRRYLLVKRYDRFTDAQGEIRRLHQEDLCQLTGY
FPSQKYERSSTGGGVTMKMMFDAVSDLVSPGERLKLLDAVIFNVLICNSDSHAKNYSILIGAGGSAKMAPLYDLMCAAVY
RQVDQSLPQGISVRFHAPDLRRADWQALADDIGLSGASTLKRVEELAKLVSVACDEVAPYIVALSSDPTRILERITHSVQ
KRCRRIQEQMRDR

Download         Length: 1242 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9667.06 Da        Isoelectric Point: 6.2834

>AT281854 WP_097099301.1 NZ_CP124964:2118003-2118275 [Agrobacterium fabacearum]
MFRSARDFGAAIKERRKALGWTQTGLAARSGTGERFIVELESGKPSCQLEKALIVARAVGIDLGDLKTVQTVQAAPDDDL
GFLPMFGADQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References