281853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 351683..352169 Replicon chromosome
Accession NZ_CP124963
Organism Agrobacterium fabacearum strain AF1/95

Toxin (Protein)


Gene name pasB Uniprot ID A0A1S7MDL2
Locus tag G6L16_RS01745 Protein ID WP_004432216.1
Coordinates 351683..351952 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1S7SNU1
Locus tag G6L16_RS01750 Protein ID WP_004432214.1
Coordinates 351936..352169 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6L16_RS01715 (G6L16_001715) 346722..347495 - 774 WP_004432233.1 L,D-transpeptidase -
G6L16_RS01720 (G6L16_001720) 347733..348362 + 630 WP_174001430.1 DNA-3-methyladenine glycosylase I -
G6L16_RS01725 (G6L16_001725) 348359..348802 + 444 WP_174001431.1 hypothetical protein -
G6L16_RS01730 (G6L16_001730) 348819..349862 - 1044 WP_174001432.1 YeiH family protein -
G6L16_RS01735 (G6L16_001735) 349945..350862 + 918 WP_174001433.1 LysR substrate-binding domain-containing protein -
G6L16_RS01740 (G6L16_001740) 350912..351676 - 765 WP_174001434.1 hypothetical protein -
G6L16_RS01745 (G6L16_001745) 351683..351952 - 270 WP_004432216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6L16_RS01750 (G6L16_001750) 351936..352169 - 234 WP_004432214.1 DUF6290 family protein Antitoxin
G6L16_RS01755 (G6L16_001755) 352326..353846 + 1521 WP_174001435.1 histidine--tRNA ligase -
G6L16_RS01760 (G6L16_001760) 354051..355178 + 1128 WP_174001436.1 ATP phosphoribosyltransferase regulatory subunit -
G6L16_RS01765 (G6L16_001765) 355175..355867 + 693 WP_004432208.1 ATP phosphoribosyltransferase -
G6L16_RS01770 (G6L16_001770) 355931..356377 - 447 WP_013635551.1 DoxX family protein -
G6L16_RS01775 (G6L16_001775) 356638..357072 - 435 WP_174001437.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(6-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10422.98 Da        Isoelectric Point: 9.9972

>T281853 WP_004432216.1 NZ_CP124963:c351952-351683 [Agrobacterium fabacearum]
MTWKIEFQHRAVKQLGKLAKQDANRIVSFLADRVVQDDNPRQTGAALQGSELGSFWRYRVGDYRIICDIQDHKLVVLVVE
IGHRREIYR

Download         Length: 270 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9225.31 Da        Isoelectric Point: 4.6044

>AT281853 WP_004432214.1 NZ_CP124963:c352169-351936 [Agrobacterium fabacearum]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRQRIANKERTYNLEEVMRDLDLEN

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S7MDL2

Antitoxin

Source ID Structure
AlphaFold DB A0A1S7SNU1

References