281829

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1847553..1848247 Replicon chromosome
Accession NZ_CP124923
Organism Enterococcus faecalis strain EfsC11

Toxin (Protein)


Gene name IrrE Uniprot ID S4BLV4
Locus tag QLQ48_RS09210 Protein ID WP_002378467.1
Coordinates 1847903..1848247 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ48_RS09205 Protein ID WP_002392358.1
Coordinates 1847553..1847885 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ48_RS09160 (1842962) 1842962..1843279 - 318 WP_002357007.1 hypothetical protein -
QLQ48_RS09165 (1843499) 1843499..1844053 + 555 WP_002357006.1 hypothetical protein -
QLQ48_RS09170 (1844338) 1844338..1844676 - 339 WP_002364347.1 hypothetical protein -
QLQ48_RS09175 (1844713) 1844713..1844922 - 210 WP_002399426.1 hypothetical protein -
QLQ48_RS09180 (1844977) 1844977..1845165 + 189 WP_002364350.1 YegP family protein -
QLQ48_RS09185 (1845191) 1845191..1845916 - 726 WP_002364352.1 phage regulatory protein -
QLQ48_RS09190 (1845955) 1845955..1846266 - 312 WP_002381719.1 hypothetical protein -
QLQ48_RS09195 (1846863) 1846863..1847060 - 198 WP_010712611.1 hypothetical protein -
QLQ48_RS09200 (1847073) 1847073..1847255 - 183 WP_002358110.1 hypothetical protein -
QLQ48_RS09205 (1847553) 1847553..1847885 + 333 WP_002392358.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ48_RS09210 (1847903) 1847903..1848247 + 345 WP_002378467.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ48_RS09215 (1848282) 1848282..1849010 + 729 WP_010784612.1 potassium channel family protein -
QLQ48_RS09220 (1849110) 1849110..1850258 + 1149 WP_002388210.1 site-specific integrase -
QLQ48_RS09225 (1850286) 1850286..1850729 - 444 WP_002388212.1 competence type IV pilus minor pilin ComGD -
QLQ48_RS09230 (1850726) 1850726..1851001 - 276 WP_002364235.1 competence type IV pilus major pilin ComGC -
QLQ48_RS09235 (1851001) 1851001..1852047 - 1047 WP_002364236.1 competence type IV pilus assembly protein ComGB -
QLQ48_RS09240 (1852004) 1852004..1852972 - 969 WP_002364237.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1810900..1869106 58206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13712.62 Da        Isoelectric Point: 5.5523

>T281829 WP_002378467.1 NZ_CP124923:1847903-1848247 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12660.01 Da        Isoelectric Point: 4.5116

>AT281829 WP_002392358.1 NZ_CP124923:1847553-1847885 [Enterococcus faecalis]
MNTYEIIKDLAKEKGISIRQLEINFGYSNGYIGSWKRQTPNSNELSRLADYFDVSVDYLLGRTDNTKATDEKKSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BLV4

Antitoxin

Source ID Structure

References