Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 11183..11717 Replicon plasmid p1_EfsC9_rep9a
Accession NZ_CP124919
Organism Enterococcus faecalis strain EfsC9

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag QLQ61_RS14350 Protein ID WP_002360769.1
Coordinates 11442..11717 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QLQ61_RS14345 Protein ID WP_002369771.1
Coordinates 11183..11449 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ61_RS14315 (7287) 7287..8072 + 786 WP_002375349.1 winged helix-turn-helix domain-containing protein -
QLQ61_RS14320 (8078) 8078..8566 + 489 WP_010774399.1 hypothetical protein -
QLQ61_RS14325 (9158) 9158..9424 + 267 WP_073495292.1 hypothetical protein -
QLQ61_RS14330 (9457) 9457..9951 + 495 WP_002375346.1 DnaJ domain-containing protein -
QLQ61_RS14335 (10048) 10048..10464 + 417 WP_002414801.1 single-stranded DNA-binding protein -
QLQ61_RS14340 (10488) 10488..11072 + 585 WP_002383617.1 thermonuclease family protein -
QLQ61_RS14345 (11183) 11183..11449 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLQ61_RS14350 (11442) 11442..11717 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
QLQ61_RS14355 (12522) 12522..12707 + 186 WP_002368099.1 hypothetical protein -
QLQ61_RS14360 (12692) 12692..12883 + 192 WP_002383620.1 DpnD/PcfM family protein -
QLQ61_RS14365 (13115) 13115..13894 + 780 WP_002383621.1 Cas9 inhibitor AcrIIA9 family protein -
QLQ61_RS14370 (13894) 13894..15153 + 1260 WP_002360763.1 PcfJ domain-containing protein -
QLQ61_RS14375 (15802) 15802..16530 + 729 WP_126266300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - prgB/asc10 1..94436 94436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T281790 WP_002360769.1 NZ_CP124919:11442-11717 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT281790 WP_002369771.1 NZ_CP124919:11183-11449 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References