Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2014531..2015172 Replicon chromosome
Accession NC_018514
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GEM_RS24645 Protein ID WP_014900129.1
Coordinates 2014531..2014869 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag GEM_RS24650 Protein ID WP_006750245.1
Coordinates 2014873..2015172 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS24635 2011073..2012506 - 1434 WP_014900127.1 aldehyde dehydrogenase family protein -
GEM_RS24640 2012535..2014175 - 1641 WP_014900128.1 acetolactate synthase large subunit -
GEM_RS24645 2014531..2014869 + 339 WP_014900129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GEM_RS24650 2014873..2015172 + 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
GEM_RS24655 2015221..2016507 - 1287 WP_014900130.1 DUF445 domain-containing protein -
GEM_RS24660 2016671..2017891 - 1221 WP_014900131.1 FAD-dependent oxidoreductase -
GEM_RS24665 2017881..2018207 - 327 WP_014900132.1 non-heme iron oxygenase ferredoxin subunit -
GEM_RS24670 2018224..2018700 - 477 WP_014900133.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
GEM_RS24675 2018715..2019986 - 1272 WP_014900134.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-109)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12623.52 Da        Isoelectric Point: 9.5939

>T28178 WP_014900129.1 NC_018514:2014531-2014869 [Burkholderia cepacia GG4]
MVDILQSMPYSAPTFSIRTTDVFDAWFAGLPDRVARRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLARLDLE

Download         Length: 339 bp

>T28178 NC_018514:2014531-2014869 [Burkholderia cepacia GG4]
ATGGTTGACATATTGCAATCCATGCCCTACAGTGCGCCTACATTCAGCATCCGGACCACCGACGTCTTCGACGCGTGGTT
TGCCGGCCTGCCGGATCGCGTCGCCCGGCGACGCATCCAGGCGCGCATCGATCGCCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCCCCCGTCGTCGAAATGCGGATCGACCACGGCCCCGGCTATCGCGTCTATTACGTCAGGCGCGGA
ACGATATGGGTGATCCTGCTCTGCGGCGGCGACAAGTCGACGCAACAGGCGGACATCCGCGCCGCGCACGCGATGCTCGC
GCGGCTCGACCTGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT28178 WP_006750245.1 NC_018514:2014873-2015172 [Burkholderia cepacia GG4]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT28178 NC_018514:2014873-2015172 [Burkholderia cepacia GG4]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGACTACTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGCGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCACTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAGGCGCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References