281771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2463589..2464284 Replicon chromosome
Accession NZ_CP124918
Organism Enterococcus faecalis strain EfsC9

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QLQ61_RS12225 Protein ID WP_002388462.1
Coordinates 2463940..2464284 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ61_RS12220 Protein ID WP_002373919.1
Coordinates 2463589..2463921 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ61_RS12170 (2459433) 2459433..2459675 - 243 WP_010716251.1 hypothetical protein -
QLQ61_RS12175 (2459676) 2459676..2459909 - 234 WP_010716252.1 hypothetical protein -
QLQ61_RS12180 (2459899) 2459899..2461113 - 1215 WP_025193233.1 DEAD/DEAH box helicase -
QLQ61_RS12185 (2461103) 2461103..2461396 - 294 WP_002418647.1 VRR-NUC domain-containing protein -
QLQ61_RS12190 (2461399) 2461399..2462082 - 684 WP_010716254.1 DUF1642 domain-containing protein -
QLQ61_RS12195 (2462193) 2462193..2462387 - 195 WP_010716255.1 hypothetical protein -
QLQ61_RS12200 (2462381) 2462381..2462581 - 201 WP_010716256.1 hypothetical protein -
QLQ61_RS12205 (2462587) 2462587..2462787 - 201 WP_002407633.1 hypothetical protein -
QLQ61_RS12210 (2462825) 2462825..2463094 - 270 WP_002365131.1 hypothetical protein -
QLQ61_RS12215 (2463107) 2463107..2463289 - 183 WP_002358110.1 hypothetical protein -
QLQ61_RS12220 (2463589) 2463589..2463921 + 333 WP_002373919.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ61_RS12225 (2463940) 2463940..2464284 + 345 WP_002388462.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ61_RS12230 (2464342) 2464342..2465070 + 729 WP_010716257.1 potassium channel family protein -
QLQ61_RS12235 (2465225) 2465225..2466406 + 1182 WP_010716258.1 site-specific integrase -
QLQ61_RS12240 (2466509) 2466509..2466658 - 150 WP_002356321.1 50S ribosomal protein L33 -
QLQ61_RS12245 (2466784) 2466784..2468919 - 2136 WP_002362471.1 penicillin-binding protein 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2422555..2466406 43851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13654.62 Da        Isoelectric Point: 5.2241

>T281771 WP_002388462.1 NZ_CP124918:2463940-2464284 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMELYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEVYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12734.28 Da        Isoelectric Point: 5.2423

>AT281771 WP_002373919.1 NZ_CP124918:2463589-2463921 [Enterococcus faecalis]
MNTYEIIKELTKRKKMSIRQLEITLGYSNGYFSKWKKVSPNSEGLQKVADYFNVSVDYLLGRTDNTKATDEKNSDDLDDV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References