281770

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1827816..1828509 Replicon chromosome
Accession NZ_CP124918
Organism Enterococcus faecalis strain EfsC9

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QLQ61_RS08960 Protein ID WP_002381718.1
Coordinates 1828165..1828509 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ61_RS08955 Protein ID WP_002364355.1
Coordinates 1827816..1828148 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ61_RS08910 (1823287) 1823287..1824021 - 735 WP_002381724.1 ERF family protein -
QLQ61_RS08915 (1824105) 1824105..1824332 - 228 WP_002381723.1 hypothetical protein -
QLQ61_RS08920 (1824552) 1824552..1825106 + 555 WP_002357006.1 hypothetical protein -
QLQ61_RS08925 (1825533) 1825533..1825727 - 195 WP_002381722.1 hypothetical protein -
QLQ61_RS08930 (1825764) 1825764..1825973 - 210 WP_002381721.1 hypothetical protein -
QLQ61_RS08935 (1826028) 1826028..1826216 + 189 WP_002357001.1 YegP family protein -
QLQ61_RS08940 (1826242) 1826242..1826967 - 726 WP_002381720.1 phage regulatory protein -
QLQ61_RS08945 (1827006) 1827006..1827317 - 312 WP_002381719.1 hypothetical protein -
QLQ61_RS08950 (1827328) 1827328..1827504 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
QLQ61_RS08955 (1827816) 1827816..1828148 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ61_RS08960 (1828165) 1828165..1828509 + 345 WP_002381718.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ61_RS08965 (1828545) 1828545..1829273 + 729 WP_002381717.1 potassium channel family protein -
QLQ61_RS08970 (1829373) 1829373..1830521 + 1149 WP_002381716.1 site-specific integrase -
QLQ61_RS08975 (1830549) 1830549..1830992 - 444 WP_002381715.1 competence type IV pilus minor pilin ComGD -
QLQ61_RS08980 (1830989) 1830989..1831264 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
QLQ61_RS08985 (1831264) 1831264..1832310 - 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
QLQ61_RS08990 (1832267) 1832267..1833235 - 969 WP_002364362.1 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1791337..1849371 58034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13784.69 Da        Isoelectric Point: 5.2350

>T281770 WP_002381718.1 NZ_CP124918:1828165-1828509 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDEQFNYSNVITHYNLKMGQETYLN

Download         Length: 345 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT281770 WP_002364355.1 NZ_CP124918:1827816-1828148 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References