Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1322560..1323599 Replicon chromosome
Accession NC_018514
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag GEM_RS21680 Protein ID WP_014899538.1
Coordinates 1322560..1323135 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag GEM_RS21685 Protein ID WP_014899539.1
Coordinates 1323132..1323599 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS21655 1317865..1318932 + 1068 WP_014899533.1 ABC transporter ATP-binding protein -
GEM_RS21660 1319114..1320205 + 1092 WP_014899534.1 porin -
GEM_RS21665 1320352..1321314 - 963 WP_014899535.1 zinc-binding alcohol dehydrogenase family protein -
GEM_RS21670 1321361..1321612 - 252 WP_014899536.1 hypothetical protein -
GEM_RS21675 1321708..1322508 + 801 WP_014899537.1 helix-turn-helix transcriptional regulator -
GEM_RS21680 1322560..1323135 - 576 WP_014899538.1 PIN domain-containing protein Toxin
GEM_RS21685 1323132..1323599 - 468 WP_014899539.1 helix-turn-helix domain-containing protein Antitoxin
GEM_RS21690 1323704..1324510 - 807 WP_014899540.1 4-hydroxy-2-oxoheptanedioate aldolase -
GEM_RS21695 1324523..1325326 - 804 WP_014899541.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
GEM_RS21700 1325347..1325739 - 393 WP_014899542.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
GEM_RS21705 1325769..1326617 - 849 WP_014899543.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
GEM_RS21710 1326670..1328133 - 1464 WP_014899544.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21599.85 Da        Isoelectric Point: 5.2544

>T28177 WP_014899538.1 NC_018514:c1323135-1322560 [Burkholderia cepacia GG4]
MTSSPFTAVYDACVLYPAPLRDFLMWLALSGCFRARWSSRIHDEWKRNLLRNRADLTAAQLDWTASLMDRAIPDALVTGY
ETLIDGLTLPDPGDRHVLAAAIRCNASVIVTFNQKDFPDEVLSIYGVEAQHPDVFADNLFDLEPAAVVTAARRQRETLKY
PPMLVDHYLEILQRLGMVQTCKALEAYRTII

Download         Length: 576 bp

>T28177 NC_018514:c1323135-1322560 [Burkholderia cepacia GG4]
ATGACGAGTTCGCCATTCACGGCGGTCTATGATGCGTGCGTGCTTTATCCCGCTCCGCTACGCGATTTCCTGATGTGGCT
TGCGTTGAGCGGCTGCTTCAGGGCCCGCTGGAGCAGCCGGATTCATGACGAGTGGAAGCGGAATCTGCTGCGAAACCGGG
CCGACCTGACCGCTGCGCAACTCGACTGGACAGCAAGCCTGATGGATCGTGCAATACCCGATGCGCTAGTGACCGGATAC
GAAACGTTGATCGACGGGCTGACGCTGCCGGATCCGGGTGATCGACACGTGCTTGCTGCTGCGATCCGCTGCAACGCCAG
TGTGATCGTAACGTTCAATCAAAAAGATTTTCCCGACGAGGTGTTGTCGATCTATGGTGTCGAAGCACAGCACCCGGATG
TGTTTGCCGATAATCTTTTCGATCTCGAGCCGGCCGCGGTTGTCACTGCAGCCCGACGACAGCGCGAAACACTGAAGTAT
CCGCCAATGTTGGTGGATCATTATCTCGAGATCCTGCAGCGTCTGGGCATGGTTCAGACCTGCAAGGCCCTCGAAGCCTA
TCGGACGATCATCTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17517.00 Da        Isoelectric Point: 6.6111

>AT28177 WP_014899539.1 NC_018514:c1323599-1323132 [Burkholderia cepacia GG4]
MPHTTMTETILPVEREMRAAVEGQRALAAYLATRTDIQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPHHKTGKHRRIRFSDLMRYKTERDQASADAMEELSRQAQKLGMGYE

Download         Length: 468 bp

>AT28177 NC_018514:c1323599-1323132 [Burkholderia cepacia GG4]
ATGCCTCACACCACGATGACCGAAACGATCTTGCCCGTCGAGCGCGAGATGCGGGCGGCTGTCGAAGGGCAGCGTGCGCT
TGCTGCGTACCTGGCAACGCGAACGGATATACAGCGTATCCAGATCTTCGACGACGAAAATCGCGCGCATCAGGTCGAAC
TTCCGACCTCCGCGCTGCGTCTGCTGGTCGATATCCTCGCCGAGCTGGCCGATGGCAATGCGGTCAAGGTCGTGCCGGTC
CATGCGGAACTGACGACGCAGGAAGCAGCCGATCTGCTCAATGTCTCTCGTCCGCACCTGATTAAGCTGCTGGAATCGAA
TGCATTGCCTCACCACAAGACTGGCAAGCATCGCCGCATACGATTTTCCGATCTGATGCGCTACAAGACGGAACGCGATC
AGGCGAGCGCAGACGCAATGGAAGAATTGAGCCGGCAGGCGCAGAAGCTTGGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References