Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 35190..35724 Replicon plasmid p1_EfsC17_rep9b
Accession NZ_CP124917
Organism Enterococcus faecalis strain EfsC17

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag QLQ62_RS14470 Protein ID WP_002360769.1
Coordinates 35449..35724 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QLQ62_RS14465 Protein ID WP_002369771.1
Coordinates 35190..35456 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ62_RS14435 (31294) 31294..32079 + 786 WP_002385543.1 replication-relaxation family protein -
QLQ62_RS14440 (32085) 32085..32573 + 489 WP_002385542.1 hypothetical protein -
QLQ62_RS14445 (33165) 33165..33431 + 267 WP_025187532.1 hypothetical protein -
QLQ62_RS14450 (33464) 33464..33958 + 495 WP_002385540.1 DnaJ domain-containing protein -
QLQ62_RS14455 (34055) 34055..34471 + 417 WP_010830229.1 single-stranded DNA-binding protein -
QLQ62_RS14460 (34495) 34495..35079 + 585 WP_010830230.1 thermonuclease family protein -
QLQ62_RS14465 (35190) 35190..35456 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLQ62_RS14470 (35449) 35449..35724 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
QLQ62_RS14475 (36527) 36527..36712 + 186 WP_002365983.1 hypothetical protein -
QLQ62_RS14480 (36697) 36697..36888 + 192 WP_002385537.1 DpnD/PcfM family protein -
QLQ62_RS14485 (37107) 37107..37886 + 780 Protein_39 Cas9 inhibitor AcrIIA9 family protein -
QLQ62_RS14490 (37886) 37886..39229 + 1344 WP_048942587.1 PcfJ domain-containing protein -
QLQ62_RS14495 (39920) 39920..40648 + 729 WP_282855872.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 1..61701 61701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T281763 WP_002360769.1 NZ_CP124917:35449-35724 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT281763 WP_002369771.1 NZ_CP124917:35190-35456 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References