Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2797117..2797688 Replicon chromosome
Accession NZ_CP124916
Organism Enterococcus faecalis strain EfsC17

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag QLQ62_RS13835 Protein ID WP_002360937.1
Coordinates 2797117..2797458 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag QLQ62_RS13840 Protein ID WP_002367500.1
Coordinates 2797458..2797688 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ62_RS13830 (2793132) 2793132..2796746 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QLQ62_RS13835 (2797117) 2797117..2797458 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QLQ62_RS13840 (2797458) 2797458..2797688 - 231 WP_002367500.1 hypothetical protein Antitoxin
QLQ62_RS13845 (2797743) 2797743..2797922 - 180 WP_111997057.1 hypothetical protein -
QLQ62_RS13850 (2798102) 2798102..2798317 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ62_RS13855 (2798456) 2798456..2799448 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ62_RS13860 (2799712) 2799712..2800350 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ62_RS13865 (2801036) 2801036..2802652 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T281759 WP_002360937.1 NZ_CP124916:c2797458-2797117 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT281759 WP_002367500.1 NZ_CP124916:c2797688-2797458 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References