28175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 632347..634097 Replicon chromosome
Accession NC_018514
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GEM_RS18680 Protein ID WP_014898929.1
Coordinates 632347..633243 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag GEM_RS18685 Protein ID WP_014898930.1
Coordinates 633240..634097 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS18650 627720..628799 - 1080 WP_014898923.1 porin -
GEM_RS18655 629248..629565 + 318 WP_014898924.1 non-heme iron oxygenase ferredoxin subunit -
GEM_RS18660 629567..629878 + 312 WP_014898925.1 hypothetical protein -
GEM_RS18665 629933..631003 + 1071 WP_014898926.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
GEM_RS18670 630996..631766 + 771 WP_014898927.1 SDR family oxidoreductase -
GEM_RS18675 631801..632328 + 528 WP_014898928.1 cupin domain-containing protein -
GEM_RS18680 632347..633243 + 897 WP_014898929.1 alpha/beta fold hydrolase Toxin
GEM_RS18685 633240..634097 + 858 WP_014898930.1 IclR family transcriptional regulator Antitoxin
GEM_RS18690 634094..634891 + 798 WP_014898931.1 SDR family oxidoreductase -
GEM_RS18695 634884..636551 + 1668 WP_014898932.1 thiamine pyrophosphate-binding protein -
GEM_RS18700 636544..637383 + 840 WP_014898933.1 aspartate dehydrogenase -
GEM_RS18705 637482..638972 + 1491 WP_014898934.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30770.93 Da        Isoelectric Point: 7.4505

>T28175 WP_014898929.1 NC_018514:632347-633243 [Burkholderia cepacia GG4]
MSVIDKRERDRTAAFAALLGQFPEQRGAAGAAGTIGYREAGAQHAGHALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLDELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAVHVGLQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDRQRGLE

Download         Length: 897 bp

>T28175 NC_018514:632347-633243 [Burkholderia cepacia GG4]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCAGCGCTGCTCGGGCAGTTTCCCGAACAGCGCGG
CGCAGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGTTGCCCGTCGTGCTGC
TGCATGGGATCGGCTCGGGTGCCGCGTCGTGGGTGCGCCAGCTCGACACGCTCGGCGCGTCGCGCCGCGTGCTCGCGTGG
GATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGGCGCGTCGCCGGCGGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGGTTGGCCC
GCGTGATGCCCGCGCGGATCGCCGGGCTGTTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GACACGCGCCGCGATGCGCGGCTGGCGATGCTCGACGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCGGGCTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCACGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGATCTCGCCGGCTTTCGCGGCCGCACGGCGGTGGCGGTCGGC
GCGAACGACGCGATCACGCCGCCGGCCGCATGCGAGCGGATCGCCGCGGCCGTGCACGTCGGGCTGCAGGTGATTCCGCA
GGCCGGTCATGCGGGGTACGTGGAGGCGCCGGCAGTCTATTCGTCGCTGATCGACACGTTCTGTCGTCAATGCGACCGTC
AACGGGGTCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31319.75 Da        Isoelectric Point: 6.6549

>AT28175 WP_014898930.1 NC_018514:633240-634097 [Burkholderia cepacia GG4]
MSEPLQQQDADNAKSEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLQALRALYPEGTLNRMTSATPESVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT28175 NC_018514:633240-634097 [Burkholderia cepacia GG4]
ATGAGCGAACCGTTGCAACAACAGGACGCAGATAACGCGAAGTCCGAGGCCAACTACGTGGTGCCTGGCCTCGAACGCGG
ACTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAACTGTCCAAGCGCCTCGGGATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAATTACAAG
CTGGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTTCAGGCGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAGCGCGAC
GCCGGAATCGGTCGACGCGCTGTATGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCCGATGGCTTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGACGACGAGCACACGTTTCTCAAAGCTTTAGGACTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References