281746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 411585..412167 Replicon chromosome
Accession NZ_CP124916
Organism Enterococcus faecalis strain EfsC17

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag QLQ62_RS02075 Protein ID WP_002355414.1
Coordinates 411859..412167 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QLQ62_RS02070 Protein ID WP_002326825.1
Coordinates 411585..411857 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ62_RS02040 (406866) 406866..407594 - 729 WP_002355404.1 GntR family transcriptional regulator -
QLQ62_RS02045 (407771) 407771..408697 + 927 WP_002355406.1 hypothetical protein -
QLQ62_RS02050 (408714) 408714..409997 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
QLQ62_RS02055 (410189) 410189..410311 + 123 Protein_380 topoisomerase -
QLQ62_RS02060 (410386) 410386..411282 + 897 WP_002363034.1 ParA family protein -
QLQ62_RS02065 (411359) 411359..411568 + 210 WP_002363035.1 peptide-binding protein -
QLQ62_RS02070 (411585) 411585..411857 + 273 WP_002326825.1 antitoxin Antitoxin
QLQ62_RS02075 (411859) 411859..412167 + 309 WP_002355414.1 zeta toxin family protein Toxin
QLQ62_RS02080 (412247) 412247..412654 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
QLQ62_RS02085 (412721) 412721..413221 - 501 WP_002363039.1 HAD family hydrolase -
QLQ62_RS02090 (413226) 413226..413993 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
QLQ62_RS02095 (414481) 414481..414906 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
QLQ62_RS02100 (414923) 414923..415438 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
QLQ62_RS02105 (415449) 415449..416381 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 379398..492828 113430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T281746 WP_002355414.1 NZ_CP124916:411859-412167 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT281746 WP_002326825.1 NZ_CP124916:411585-411857 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References