Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 34631..35165 Replicon plasmid p1_EfsC8_rep9c
Accession NZ_CP124915
Organism Enterococcus faecalis strain EfsC8

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag QLQ37_RS12975 Protein ID WP_002360769.1
Coordinates 34890..35165 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QLQ37_RS12970 Protein ID WP_002369771.1
Coordinates 34631..34897 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ37_RS12940 (QLQ37_12940) 30734..31519 + 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -
QLQ37_RS12945 (QLQ37_12945) 31525..32013 + 489 WP_002368088.1 hypothetical protein -
QLQ37_RS12950 (QLQ37_12950) 32605..32871 + 267 WP_002368091.1 hypothetical protein -
QLQ37_RS12955 (QLQ37_12955) 32904..33398 + 495 WP_002368092.1 DnaJ domain-containing protein -
QLQ37_RS12960 (QLQ37_12960) 33496..33912 + 417 WP_002368093.1 single-stranded DNA-binding protein -
QLQ37_RS12965 (QLQ37_12965) 33936..34520 + 585 WP_002368095.1 thermonuclease family protein -
QLQ37_RS12970 (QLQ37_12970) 34631..34897 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLQ37_RS12975 (QLQ37_12975) 34890..35165 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
QLQ37_RS12980 (QLQ37_12980) 35967..36152 + 186 WP_002365983.1 hypothetical protein -
QLQ37_RS12985 (QLQ37_12985) 36137..36328 + 192 WP_002385537.1 DpnD/PcfM family protein -
QLQ37_RS12990 (QLQ37_12990) 36548..37327 + 780 WP_002385536.1 Cas9 inhibitor AcrIIA9 family protein -
QLQ37_RS12995 (QLQ37_12995) 37327..38670 + 1344 WP_048942587.1 PcfJ domain-containing protein -
QLQ37_RS13000 (QLQ37_13000) 39361..40089 + 729 WP_025187535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) prgB/asc10 1..52618 52618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T281744 WP_002360769.1 NZ_CP124915:34890-35165 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT281744 WP_002369771.1 NZ_CP124915:34631-34897 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References