Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2309686..2310725 Replicon chromosome
Accession NZ_CP124914
Organism Enterococcus faecalis strain EfsC8

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag QLQ37_RS11020 Protein ID WP_010824179.1
Coordinates 2310066..2310725 (+) Length 220 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag QLQ37_RS11015 Protein ID WP_010824178.1
Coordinates 2309686..2310069 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ37_RS10960 (2305514) 2305514..2305882 - 369 WP_002365216.1 DUF86 domain-containing protein -
QLQ37_RS10965 (2305866) 2305866..2306198 - 333 WP_002399122.1 nucleotidyltransferase domain-containing protein -
QLQ37_RS10970 (2306258) 2306258..2306581 - 324 WP_002399121.1 hypothetical protein -
QLQ37_RS10975 (2306621) 2306621..2306782 - 162 WP_229236153.1 hypothetical protein -
QLQ37_RS10980 (2306871) 2306871..2307023 - 153 WP_002399525.1 hypothetical protein -
QLQ37_RS10985 (2307050) 2307050..2307274 - 225 WP_010824177.1 hypothetical protein -
QLQ37_RS10990 (2307506) 2307506..2307694 + 189 WP_002365223.1 hypothetical protein -
QLQ37_RS10995 (2307681) 2307681..2307842 - 162 WP_002365224.1 hypothetical protein -
QLQ37_RS11000 (2307865) 2307865..2308281 - 417 WP_002408315.1 DUF961 family protein -
QLQ37_RS11005 (2308281) 2308281..2308607 - 327 WP_010710084.1 hypothetical protein -
QLQ37_RS11010 (2308693) 2308693..2308944 - 252 WP_010777935.1 hypothetical protein -
QLQ37_RS11015 (2309686) 2309686..2310069 + 384 WP_010824178.1 helix-turn-helix transcriptional regulator Antitoxin
QLQ37_RS11020 (2310066) 2310066..2310725 + 660 WP_010824179.1 ImmA/IrrE family metallo-endopeptidase Toxin
QLQ37_RS11025 (2310741) 2310741..2311076 + 336 WP_010824180.1 helix-turn-helix domain-containing protein -
QLQ37_RS11030 (2311114) 2311114..2312445 - 1332 WP_010824181.1 FAD-dependent oxidoreductase -
QLQ37_RS11035 (2312545) 2312545..2313480 - 936 WP_174115432.1 aldo/keto reductase -
QLQ37_RS11040 (2313495) 2313495..2313914 - 420 WP_002365234.1 MerR family transcriptional regulator -
QLQ37_RS11045 (2313931) 2313931..2314512 - 582 WP_002380883.1 histidine phosphatase family protein -
QLQ37_RS11050 (2314734) 2314734..2315063 + 330 WP_010816770.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2270911..2317246 46335


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(80-181)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 220 a.a.        Molecular weight: 26320.31 Da        Isoelectric Point: 7.0496

>T281740 WP_010824179.1 NZ_CP124914:2310066-2310725 [Enterococcus faecalis]
MIGLLWVDFISKKLYFEAFNFSNKLIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLIYVNNCTFAHANTLFNNYYFHKETDIYRFIFNDS

Download         Length: 660 bp

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 15032.08 Da        Isoelectric Point: 5.3750

>AT281740 WP_010824178.1 NZ_CP124914:2309686-2310069 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKKRNKKD

Download         Length: 384 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References