Detailed information of TA system TA281740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ImmA-IrrE/HTH_19(antitoxin)
• Location: 2309686..2310725
• Replicon: chromosome
• Accession: NZ_CP124914
• Organism: Enterococcus faecalis strain EfsC8

Toxin (Protein)

• Gene name: IrrE
• Uniprot ID: -
• Locus tag: QLQ37_RS11020
• Protein ID: WP_010824179.1
• Coordinates: 2310066..2310725 (+)
• Length: 220 a.a.

Antitoxin (Protein)

• Gene name: ImmA
• Uniprot ID: -
• Locus tag: QLQ37_RS11015
• Protein ID: WP_010824178.1
• Coordinates: 2309686..2310069 (+)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ37_RS10960 (2305514)	2305514..2305882	-	369	WP_002365216.1	DUF86 domain-containing protein	-
QLQ37_RS10965 (2305866)	2305866..2306198	-	333	WP_002399122.1	nucleotidyltransferase domain-containing protein	-
QLQ37_RS10970 (2306258)	2306258..2306581	-	324	WP_002399121.1	hypothetical protein	-
QLQ37_RS10975 (2306621)	2306621..2306782	-	162	WP_229236153.1	hypothetical protein	-
QLQ37_RS10980 (2306871)	2306871..2307023	-	153	WP_002399525.1	hypothetical protein	-
QLQ37_RS10985 (2307050)	2307050..2307274	-	225	WP_010824177.1	hypothetical protein	-
QLQ37_RS10990 (2307506)	2307506..2307694	+	189	WP_002365223.1	hypothetical protein	-
QLQ37_RS10995 (2307681)	2307681..2307842	-	162	WP_002365224.1	hypothetical protein	-
QLQ37_RS11000 (2307865)	2307865..2308281	-	417	WP_002408315.1	DUF961 family protein	-
QLQ37_RS11005 (2308281)	2308281..2308607	-	327	WP_010710084.1	hypothetical protein	-
QLQ37_RS11010 (2308693)	2308693..2308944	-	252	WP_010777935.1	hypothetical protein	-
QLQ37_RS11015 (2309686)	2309686..2310069	+	384	WP_010824178.1	helix-turn-helix transcriptional regulator	Antitoxin
QLQ37_RS11020 (2310066)	2310066..2310725	+	660	WP_010824179.1	ImmA/IrrE family metallo-endopeptidase	Toxin
QLQ37_RS11025 (2310741)	2310741..2311076	+	336	WP_010824180.1	helix-turn-helix domain-containing protein	-
QLQ37_RS11030 (2311114)	2311114..2312445	-	1332	WP_010824181.1	FAD-dependent oxidoreductase	-
QLQ37_RS11035 (2312545)	2312545..2313480	-	936	WP_174115432.1	aldo/keto reductase	-
QLQ37_RS11040 (2313495)	2313495..2313914	-	420	WP_002365234.1	MerR family transcriptional regulator	-
QLQ37_RS11045 (2313931)	2313931..2314512	-	582	WP_002380883.1	histidine phosphatase family protein	-
QLQ37_RS11050 (2314734)	2314734..2315063	+	330	WP_010816770.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2270911..2317246	46335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (80-181)

Antitoxin

• Cro/C1-type helix-turn-helix domain (5-63)

Sequences

Toxin

Protein

• Length: 220 a.a.
• Molecular weight: 26320.31 Da
• Isoelectric Point: 7.0496

>T281740 WP_010824179.1 NZ_CP124914:2310066-2310725 [Enterococcus faecalis]
MIGLLWVDFISKKLYFEAFNFSNKLIKEVSYYSSKNIEQVKCFDIEKYVKEVEDVEFVEYTFQKQLKRRMLGSISKVDDE
VIITTNKELMLERKNFTKMHEVMHYYIDIPKINNATHTFSDILLKNGYLMEDFPKEYRANVGASMLMANDQALFYALKKF
YSFEEIAQYFFMSKSALRNRLIEHLIYVNNCTFAHANTLFNNYYFHKETDIYRFIFNDS

Nucleotide

• Length: 660 bp

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 15032.08 Da
• Isoelectric Point: 5.3750

>AT281740 WP_010824178.1 NZ_CP124914:2309686-2310069 [Enterococcus faecalis]
VQPLAKRLQLLREEKEWTKTYVAKQLGLNNLGTYANWEYGTREPDSEMLSKIASLYDVSTDFLLGRTEERIHLNDKEKIG
KNIISHFRLNTSDMDIEDIEELEEELIDFQDFLIKKAKEKKKRNKKD

Nucleotide

• Length: 384 bp