Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 513623..514278 Replicon chromosome
Accession NC_018514
Organism Burkholderia cepacia GG4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GEM_RS18095 Protein ID WP_014898815.1
Coordinates 513859..514278 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GEM_RS30230 Protein ID WP_014898814.1
Coordinates 513623..513862 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEM_RS18070 509442..509567 - 126 Protein_460 PIN domain-containing protein -
GEM_RS18075 509617..510300 - 684 WP_041490735.1 Fe2+-dependent dioxygenase -
GEM_RS18080 510297..511053 - 757 Protein_462 sel1 repeat family protein -
GEM_RS18085 511057..513300 - 2244 WP_014898813.1 TonB-dependent siderophore receptor -
GEM_RS30230 513623..513862 + 240 WP_014898814.1 Arc family DNA-binding protein Antitoxin
GEM_RS18095 513859..514278 + 420 WP_014898815.1 type II toxin-antitoxin system VapC family toxin Toxin
GEM_RS18100 514421..515716 - 1296 WP_014898816.1 aspartate carbamoyltransferase -
GEM_RS18105 515956..516090 + 135 WP_006485835.1 entericidin A/B family lipoprotein -
GEM_RS18110 516181..516753 - 573 WP_014898817.1 hypothetical protein -
GEM_RS18115 517091..518050 - 960 WP_041490906.1 DMT family transporter -
GEM_RS18120 518252..519046 - 795 WP_014898819.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14998.22 Da        Isoelectric Point: 7.0177

>T28174 WP_014898815.1 NC_018514:513859-514278 [Burkholderia cepacia GG4]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEIRFGVAALPEGRRRDWLHQSVEQRVVPLFRGRILAFDD
AASKAYASLRAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAR

Download         Length: 420 bp

>T28174 NC_018514:513859-514278 [Burkholderia cepacia GG4]
ATGATCCTGGTCGATACCAACGTCATTTCCGAGCCGCTGCGACGCGAACCGAGCGCAGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAAATCCGCTTCGGTGTGGCGGCCTTGCCGGAAGGGC
GAAGGCGGGACTGGCTGCACCAGAGCGTCGAGCAGCGTGTCGTGCCGCTGTTTCGCGGTCGGATCCTTGCGTTCGACGAT
GCGGCCAGTAAAGCGTATGCGAGCCTTCGCGCGAAGGCGCGTGCTACGGGCAACGCGATGGCGTCTGCCGATGGCTTTAT
CGCTGCAACAGCCGCAGCGAACGGCCTGATCGTGGCCACGCGCGACGTCGCGCCGTTCGAAGCAGCGGGCCTGCGCGTGA
TCGACCCGTGGGCCCGGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8736.89 Da        Isoelectric Point: 5.7012

>AT28174 WP_014898814.1 NC_018514:513623-513862 [Burkholderia cepacia GG4]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLAEIGREAGGIDLEVQRDQAPSEPMSFE

Download         Length: 240 bp

>AT28174 NC_018514:513623-513862 [Burkholderia cepacia GG4]
ATGCCCGTGATCACTGTTCGAAATCTGCCCGACGAGGTGCATCGCGCGCTTCGAATCCGTGCTGCGCAACATGGCCGCAG
TACCGAGGCCGAGGTACGCGACATCCTCGAGCAAGCCGTCCGGCCCGGTGGGCGCCCCAGGCTGGGAACGCTGCTGGCTG
AAATCGGGCGCGAGGCTGGTGGCATCGATCTCGAGGTTCAGCGCGACCAAGCGCCATCCGAACCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References