281734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 2668273..2668807 Replicon chromosome
Accession NZ_CP124913
Organism Enterococcus faecalis strain EfsC20

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag QLQ32_RS12815 Protein ID WP_002360769.1
Coordinates 2668273..2668548 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QLQ32_RS12820 Protein ID WP_002369771.1
Coordinates 2668541..2668807 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ32_RS12785 (2663321) 2663321..2664259 - 939 WP_002370935.1 2-dehydropantoate 2-reductase -
QLQ32_RS12790 (2664387) 2664387..2664716 - 330 WP_002358661.1 LPXTG cell wall anchor domain-containing protein -
QLQ32_RS12795 (2664746) 2664746..2664931 + 186 WP_002358660.1 hypothetical protein -
QLQ32_RS12800 (2664963) 2664963..2665571 + 609 Protein_2512 IS6 family transposase -
QLQ32_RS12805 (2666240) 2666240..2667214 - 975 WP_002355428.1 choloylglycine hydrolase -
QLQ32_RS12810 (2667438) 2667438..2668082 + 645 WP_002377952.1 IS6 family transposase -
QLQ32_RS12815 (2668273) 2668273..2668548 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
QLQ32_RS12820 (2668541) 2668541..2668807 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QLQ32_RS12825 (2668918) 2668918..2669502 - 585 WP_002377949.1 thermonuclease family protein -
QLQ32_RS12830 (2669526) 2669526..2669942 - 417 WP_010710134.1 single-stranded DNA-binding protein -
QLQ32_RS12835 (2670018) 2670018..2670266 - 249 WP_002360773.1 DUF3850 domain-containing protein -
QLQ32_RS12840 (2670279) 2670279..2670779 - 501 WP_002360775.1 DnaJ domain-containing protein -
QLQ32_RS12845 (2670812) 2670812..2671078 - 267 WP_002377947.1 hypothetical protein -
QLQ32_RS12850 (2671670) 2671670..2672158 - 489 WP_010710133.1 hypothetical protein -
QLQ32_RS12855 (2672164) 2672164..2672757 - 594 WP_002414802.1 replication-relaxation family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T281734 WP_002360769.1 NZ_CP124913:c2668548-2668273 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT281734 WP_002369771.1 NZ_CP124913:c2668807-2668541 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References